Shoupe D, Mishell D R, Lacarra M, Lobo R A, Horenstein J, d'Ablaing G, Moyer D
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
Obstet Gynecol. 1989 Jan;73(1):88-92.
Dating of maturity of the endometrium by histologic examination was correlated with four methods of ovulation detection in 13 cycling parous women. Histologic dating was assessed independently by two pathologists and correlated with the postovulatory duration as determined by daily transvaginal ultrasound scanning, serum LH measurements, basal body temperature (BBT), and subtraction of 14 days from the onset of menses. In addition, progesterone and estradiol (E2) were measured in daily serum samples. Dating of the endometrial biopsy was highly correlated (P less than .002) with the day of ovulation as determined by ultrasound, and was found to be within 2 days of the correct postovulatory day on evaluation of 25 of 26 (96.1%) of the interpretations. The accuracy of dating using the LH surge was 84.6% (22 of 26 interpretations), and with the BBT thermogenic shift was 76.9% (20 of 26 interpretations). However, dating of the endometrium was within 2 days of the correct day in only 17 of the 26 interpretations as determined by subtracting 14 days from the onset of the subsequent menses. The accuracy of dating was significantly better correlated (P less than .025) with days from ovulation as determined by ultrasound than as calculated from the onset of menses. There was a significant correlation between endometrial dating and the amount of progesterone (P less than .01) and E2 (P less than .01) secreted from the day of ovulation, as determined by transvaginal ultrasound, to the day of biopsy. These data confirm a strong correlation between endometrial dating and ovarian hormone secretion during the postovulatory phase.(ABSTRACT TRUNCATED AT 250 WORDS)
通过组织学检查确定子宫内膜成熟时间，并与13名有生育史的周期性妇女的四种排卵检测方法进行关联。由两名病理学家独立评估组织学测定结果，并与通过每日经阴道超声扫描、血清促黄体生成素（LH）测量、基础体温（BBT）以及从月经开始日减去14天所确定的排卵后持续时间相关联。此外，每天采集血清样本测量孕酮和雌二醇（E2）。子宫内膜活检的测定结果与超声确定的排卵日高度相关（P＜0.002），在26次解读中有25次（96.1%）的评估结果显示其在正确的排卵后天数的2天范围内。使用LH峰进行测定的准确率为84.6%（26次解读中有22次），使用BBT体温变化的准确率为76.9%（26次解读中有20次）。然而，通过从随后月经开始日减去14天来确定，在26次解读中只有17次子宫内膜测定结果在正确天数的2天范围内。与根据月经开始日计算相比，根据超声确定的排卵天数，测定结果的准确率与排卵天数的相关性显著更好（P＜0.025）。从经阴道超声确定的排卵日到活检日，子宫内膜测定结果与孕酮（P＜0.01）和E2（P＜0.01）的分泌量之间存在显著相关性。这些数据证实了排卵后阶段子宫内膜测定与卵巢激素分泌之间存在强相关性。（摘要截选至250字）
