Department of Research, Olmsted Medical Center, Rochester, MN, USA.
Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, AZ, USA.
NPJ Prim Care Respir Med. 2015 Oct 1;25:15058. doi: 10.1038/npjpcrm.2015.58.
Asthma prevalence, severity and outcomes are associated with various patient characteristics and lifestyle choices.
To identify potentially modifiable factors associated with poor asthma outcomes among US primary care patients.
Using baseline data from the Asthma Tools Study, we calculated cross-sectional frequencies of activity levels, smoking, secondhand smoke exposure and the presence of obesity, as well as rates of out-of-control asthma and asthma exacerbations. Frequencies were stratified by sex, and into three age groups: 5-11 years, 12-18 years and 19 years and older. Logistic regression was used to identify factors associated with each of the asthma outcomes.
In the 901 individuals enrolled in this asthma study, tobacco smoke exposure, obesity, low activity levels, poverty, inadequately controlled asthma and high asthma-related health-care utilisation were common. Across all age groups, obesity was associated with poorer asthma outcomes: either poor asthma control (odds ratio (OR)=2.3, 95% confidence interval (CI) 1.1-4.7 in 5- to 11-year-olds and OR=1.5, 95% CI 1.1-2.2 in adults) or asthma exacerbations (OR 2.9, 95% CI 1.6-5.1 in 12- to 18-year-olds and OR 1.7, 95% CI 1.1-2.5 in adults). Among adults, smoking was associated with both measures of poorer asthma outcomes; inadequate asthma control (OR=2.3, 95% CI 1.5-3.5), and asthma exacerbations (OR 1.7, 95% CI 1.1-2.6), and low physical activity were associated with poor asthma control (OR=1.5, 95% CI 1.1-2.2).
Obesity, low levels of physical activity and smoking are common, and they are associated with poor asthma outcomes in a sample of primary care patients, suggesting important targets for intervention.
哮喘的患病率、严重程度和结局与患者的各种特征和生活方式选择有关。
确定与美国初级保健患者不良哮喘结局相关的潜在可改变因素。
利用哮喘工具研究的基线数据,我们计算了活动水平、吸烟、二手烟暴露以及肥胖的存在情况,以及哮喘失控和哮喘加重的发生率。按性别和三个年龄组(5-11 岁、12-18 岁和 19 岁及以上)进行分层。采用逻辑回归来确定与每种哮喘结局相关的因素。
在这项哮喘研究中,901 名入组患者中,烟草烟雾暴露、肥胖、活动水平低、贫困、哮喘控制不佳和高哮喘相关医疗保健利用很常见。在所有年龄组中,肥胖与较差的哮喘结局相关:要么是哮喘控制不佳(5-11 岁患者的比值比(OR)为 2.3,95%置信区间(CI)为 1.1-4.7,成人 OR 为 1.5,95%CI 为 1.1-2.2),要么是哮喘加重(12-18 岁患者的 OR 为 2.9,95%CI 为 1.6-5.1,成人 OR 为 1.7,95%CI 为 1.1-2.5)。在成人中,吸烟与两种衡量较差的哮喘结局都相关:哮喘控制不佳(OR=2.3,95%CI 1.5-3.5)和哮喘加重(OR 1.7,95%CI 1.1-2.6),体力活动不足与哮喘控制不佳(OR=1.5,95%CI 1.1-2.2)相关。
肥胖、体力活动水平低和吸烟很常见,并且与初级保健患者样本中较差的哮喘结局相关,这表明有重要的干预目标。