Chou Yin-Yi, Lai Kuo-Lung, Chen Der-Yuan, Lin Ching-Heng, Chen Hsin-Hua
Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
PLoS One. 2015 Oct 1;10(10):e0139693. doi: 10.1371/journal.pone.0139693. eCollection 2015.
The risk of periodontitis (PD) is increased in the patient group of rheumatoid arthritis (RA). RA and PD also shared some pathological mechanism. The aim of this study is to investigate the risk of RA associated with PD exposure.
This study identified 3 mutually exclusive cohorts using the 1999-2010 Taiwanese National Health Insurance Research Database (NHIRD) to investigate the association between PD and the risk of incident RA. All patients with PD in 2000 were identified from the database of all enrollees as the PD cohort. From the representative database of 1,000,000 enrollees randomly selected in 2010 (LHID2010), individuals without any periodontal disease (PO) during 1999-2010 were selected as the non-PO cohort. Individuals who were not included in the non-PO cohort and received dental scaling (DS) no more than two times per year during 1999-2010 were selected as the DS cohort from LHID2010. Using cox proportional regression analysis, hazard ratios (HRs) with 95% confidence intervals (Cis) were calculated to quantify the association between PD exposure and RA development. In the three-group comparison using the non-PO cohort as reference, we found that the risk of RA was higher in the PD and DS cohorts (HRs, 1.89 and 1.43; 95% CIs, 1.56-2.29 and 1.09-1.87, respectively). For comparisons between two cohorts, the PD cohort had a higher risk of RA than the non-PO and DS cohorts (HRs, 1.91 and 1.35; 95% CIs, 1.57-2.30 and 1.09-1.67, respectively).
PD was associated with an increased risk of RA development.
类风湿关节炎（RA）患者群体中患牙周炎（PD）的风险增加。RA和PD也有一些共同的病理机制。本研究的目的是调查与PD暴露相关的RA风险。
本研究使用1999 - 2010年台湾国民健康保险研究数据库（NHIRD）确定了3个相互排斥的队列，以调查PD与新发RA风险之间的关联。2000年所有患有PD的患者从所有参保者数据库中被确定为PD队列。从2010年随机选取的100万参保者的代表性数据库（LHID2010）中，选取1999 - 2010年期间无任何牙周疾病（PO）的个体作为非PO队列。未纳入非PO队列且在1999 - 2010年期间每年接受洗牙（DS）不超过两次的个体从LHID2010中被选为DS队列。使用Cox比例回归分析，计算风险比（HRs）及95%置信区间（Cis）以量化PD暴露与RA发生之间的关联。在以非PO队列为参照的三组比较中，我们发现PD队列和DS队列中RA的风险更高（HRs分别为1.89和1.43；95% CIs分别为1.56 - 2.29和1.09 - 1.87）。在两个队列之间的比较中，PD队列患RA的风险高于非PO队列和DS队列（HRs分别为1.91和1.35；95% CIs分别为1.57 - 2.30和1.09 - 1.67）。
PD与RA发生风险增加相关。
