Argilés J, Herrera E
Catedra de Fisiologia General, Facultad de Biologia, Universidad de Barcelona, Spain.
Metabolism. 1989 Feb;38(2):104-8. doi: 10.1016/0026-0495(89)90247-3.
Studies were performed to determine whether and/or how dietary lipids participate in maternal hypertriglyceridemia during late gestation in the rat. After oral administration of glycerol-tri(1-14C)-palmitate, total radioactivity in plasma increased more rapidly in 20-day pregnant rats than in either 19-day pregnant rats or virgin controls. At the peak of plasma radioactivity, four hours after the tracer was administered, most of the plasma label corresponded to 14C-lipids in triglyceride-rich lipoproteins (d less than 1.006), and when expressed per micromol of triglyceride, values were higher in pregnant than in virgin rats. The difference was less after 24 hours, although at this time the level of 14C-lipids in d less than 1.006 lipoproteins was still higher in 20-day pregnant rats than in virgins. Tissue 14C-lipids, as expressed per gram of fresh weight, were similar in pregnant and virgin rats, but the values in mammary glands were much higher in the former group. Estimated recovery of administered radioactivity four hours after tracer in total white adipose tissue, mammary glands, and plasma lipids was higher in pregnant than in virgin rats. No difference was found between 20-day pregnant and virgin rats either in the label retained in the gastrointestinal tract or in that exhaled as 14C-CO2 during the first four hours following oral administration of 14C-tripalmitate. These findings plus the known maternal hyperphagia, indicate that in the rat at late pregnancy triglyceride intestinal absorption is unchanged or even enhanced and that dietary lipids actively contribute to both maternal hypertriglyceridemia and lipid uptake by the mammary gland.
开展了多项研究，以确定膳食脂质是否以及如何参与大鼠妊娠后期的母体高甘油三酯血症。口服甘油 - 三（1 - 14C） - 棕榈酸酯后，20天妊娠大鼠血浆中的总放射性比19天妊娠大鼠或未孕对照大鼠增加得更快。在给予示踪剂4小时后血浆放射性达到峰值时，大部分血浆标记物对应于富含甘油三酯的脂蛋白（d小于1.006）中的14C - 脂质，并且以每微摩尔甘油三酯表示时，妊娠大鼠的值高于未孕大鼠。24小时后差异较小，尽管此时20天妊娠大鼠中d小于1.006的脂蛋白中的14C - 脂质水平仍高于未孕大鼠。按每克鲜重表示的组织14C - 脂质在妊娠大鼠和未孕大鼠中相似，但乳腺中的值在前一组中要高得多。妊娠大鼠中，在给予示踪剂4小时后，白色脂肪组织、乳腺和血浆脂质中给予的放射性估计回收率高于未孕大鼠。在口服14C - 三棕榈酸酯后的前4小时内，20天妊娠大鼠和未孕大鼠在胃肠道中保留的标记物或呼出的14C - CO2方面均未发现差异。这些发现加上已知的母体摄食过量，表明在大鼠妊娠后期，甘油三酯的肠道吸收未改变甚至增强，并且膳食脂质积极促成母体高甘油三酯血症和乳腺对脂质的摄取。
