• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

卵圆孔未闭与卒中——现状。

Patent Foramen Ovale and Stroke-Current Status.

机构信息

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Department of Neurology, National Medical Center, Seoul, Korea.

出版信息

J Stroke. 2015 Sep;17(3):229-37. doi: 10.5853/jos.2015.17.3.229. Epub 2015 Sep 30.

DOI:10.5853/jos.2015.17.3.229
PMID:26437990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4635723/
Abstract

Patent foramen ovale (PFO) is growing in clinical interest because of a renewed focus on embolic stroke of undetermined source (ESUS), the PFO attributable fraction (the 10-point Risk of Paradoxical Embolism score), technical advances in PFO diagnosis, and the emergence of endovascular device closure as a treatment option. However, recent randomized controlled trials of the management of patients with ESUS and PFO failed to demonstrate the superiority of closure over medical treatment. The mechanisms of stroke other than paradoxical embolism may be important in patients with ESUS and PFO. This paper reviews the current understanding of the pathophysiology of stroke and therapeutic options in patients with PFO and ESUS.

摘要

卵圆孔未闭（PFO）在临床研究中的关注度不断增加，主要是由于人们对不明来源栓塞性卒中（ESUS）、PFO 相关比例（10 分矛盾栓塞风险评分）、PFO 诊断技术进步以及血管内装置封堵术作为一种治疗选择的重新关注。然而，最近针对 ESUS 和 PFO 患者管理的随机对照试验未能证明封堵术优于药物治疗。除了矛盾栓塞之外的其他卒中机制在 ESUS 和 PFO 患者中可能很重要。本文综述了目前对 PFO 和 ESUS 患者卒中病理生理学和治疗选择的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/c1749f402d43/jos-17-3-229f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/f92a545abb83/jos-17-3-229f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/864bbcc5c1e1/jos-17-3-229f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/8537427421e4/jos-17-3-229f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/32ae89f35c94/jos-17-3-229f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/7303009ba17c/jos-17-3-229f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/c1749f402d43/jos-17-3-229f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/f92a545abb83/jos-17-3-229f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/864bbcc5c1e1/jos-17-3-229f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/8537427421e4/jos-17-3-229f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/32ae89f35c94/jos-17-3-229f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/7303009ba17c/jos-17-3-229f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce7a/4635723/c1749f402d43/jos-17-3-229f6.jpg

相似文献

1
Patent Foramen Ovale and Stroke-Current Status.卵圆孔未闭与卒中——现状。
J Stroke. 2015 Sep;17(3):229-37. doi: 10.5853/jos.2015.17.3.229. Epub 2015 Sep 30.
2
Embolic Stroke of Undetermined Source and Patent Foramen Ovale: Risk of Paradoxical Embolism Score Validation and Atrial Fibrillation Prediction.不明来源栓塞性脑卒中与卵圆孔未闭：矛盾栓塞风险评分验证与心房颤动预测。
Stroke. 2021 May;52(5):1643-1652. doi: 10.1161/STROKEAHA.120.032453. Epub 2021 Mar 31.
3
Dabigatran or Aspirin After Embolic Stroke of Undetermined Source in Patients With Patent Foramen Ovale: Results From RE-SPECT ESUS.卵圆孔未闭伴不明来源栓塞性卒中患者应用达比加群或阿司匹林治疗：RE-SPECT ESUS 研究结果。
Stroke. 2021 Mar;52(3):1065-1068. doi: 10.1161/STROKEAHA.120.031237. Epub 2021 Jan 28.
4
Comparison of echocardiographic and clinical characteristics in embolic stroke and migraine patients with patent foramen ovale.卵圆孔未闭伴栓塞性脑卒中与偏头痛患者的超声心动图与临床特征比较。
Echocardiography. 2024 Feb;41(2):e15770. doi: 10.1111/echo.15770.
5
Transcatheter Closure of Patent Foramen Ovale: Randomized Trial Update.经导管封堵卵圆孔未闭：随机试验更新
Interv Cardiol Clin. 2019 Oct;8(4):341-356. doi: 10.1016/j.iccl.2019.05.002. Epub 2019 Jul 27.
6
Carotid Atherosclerosis and Patent Foramen Ovale in Embolic Stroke of Undetermined Source.不明来源栓塞性卒中与颈动脉粥样硬化及卵圆孔未闭。
J Stroke Cerebrovasc Dis. 2021 Jan;30(1):105409. doi: 10.1016/j.jstrokecerebrovasdis.2020.105409. Epub 2020 Nov 1.
7
Predictors of recurrent events in patients with cryptogenic stroke and patent foramen ovale within the CLOSURE I (Evaluation of the STARFlex Septal Closure System in Patients With a Stroke and/or Transient Ischemic Attack Due to Presumed Paradoxical Embolism Through a Patent Foramen Ovale) trial.CLOSURE I（评价 STARFlex 间隔封堵系统在因推测性反常栓塞引起的脑卒中和/或短暂性脑缺血发作的卵圆孔未闭患者中的应用）试验中，不明原因卒中合并卵圆孔未闭患者复发性事件的预测因素。
JACC Cardiovasc Interv. 2014 Aug;7(8):913-20. doi: 10.1016/j.jcin.2014.01.170.
8
Potential Embolic Sources in Embolic Stroke of Undetermined Source Patients with Patent Foramen Ovale.卵圆孔未闭伴不明来源栓塞性脑卒中患者的潜在栓塞源。
Cerebrovasc Dis. 2023;52(5):503-510. doi: 10.1159/000527791. Epub 2022 Dec 1.
9
Patent Foramen Ovale and Other Cardiopathies as Causes of Embolic Stroke With Unknown Source.卵圆孔未闭及其他心脏病作为不明来源栓塞性卒中的病因
J Stroke. 2024 Sep;26(3):349-359. doi: 10.5853/jos.2024.02670. Epub 2024 Sep 30.
10
Localization of Infratentorial Lesion could Predict Patent Foramen Ovale as an Etiology in Embolic Stroke of Undetermined Source.小脑病变的定位可预测卵圆孔未闭在不明来源栓塞性卒中中的病因学作用。
J Atheroscler Thromb. 2022 May 1;29(5):785-793. doi: 10.5551/jat.61200. Epub 2021 May 1.

引用本文的文献

1
Isolated Aphasia From a Left Parietotemporal Infarct Secondary to a Patent Foramen Ovale: A Case Report.卵圆孔未闭继发左顶颞叶梗死导致的孤立性失语：一例报告
Cureus. 2025 May 23;17(5):e84678. doi: 10.7759/cureus.84678. eCollection 2025 May.
2
Cardiac CT in Large Vessel Occlusion Stroke for the Evaluation of Non-Thrombotic and Non-Atrial-Fibrillation-Related Embolic Causes.用于评估非血栓性和非房颤相关性栓塞原因的大血管闭塞性卒中的心脏CT
Neurol Int. 2025 Feb 7;17(2):25. doi: 10.3390/neurolint17020025.
3
The Relationship Between the Triglyceride-Glucose Index and Cryptogenic Stroke in Patients with Patent Foramen Ovale.

本文引用的文献

1
D-dimer for prediction of long-term outcome in cryptogenic stroke patients with patent foramen ovale.D-二聚体用于预测卵圆孔未闭的隐源性卒中患者的长期预后。
Thromb Haemost. 2015 Aug 31;114(3):614-22. doi: 10.1160/TH14-12-1040. Epub 2015 May 21.
2
Left atrial enlargement and stroke recurrence: the Northern Manhattan Stroke Study.左心房扩大与卒中复发：北曼哈顿卒中研究
Stroke. 2015 Jun;46(6):1488-93. doi: 10.1161/STROKEAHA.115.008711. Epub 2015 Apr 23.
3
Brief history of patent foramen ovale and stroke.卵圆孔未闭与中风简史
卵圆孔未闭患者甘油三酯-葡萄糖指数与隐源性卒中的关系
Clin Appl Thromb Hemost. 2024 Jan-Dec;30:10760296241301411. doi: 10.1177/10760296241301411.
4
Association between sedentary time, physical activity, biochemical markers in the blood (heart and muscles) and heart failure in adults with congenital heart disease: a study protocol of a cross-sectional cohort study in Sweden (the ACHD trial protocol).成年人先天性心脏病患者的久坐时间、身体活动、血液生化标志物（心脏和肌肉）与心力衰竭之间的关联：瑞典一项横断面队列研究的研究方案（ACHD 试验方案）。
BMJ Open. 2024 Nov 20;14(11):e087907. doi: 10.1136/bmjopen-2024-087907.
5
Patent Foramen Ovale and Other Cardiopathies as Causes of Embolic Stroke With Unknown Source.卵圆孔未闭及其他心脏病作为不明来源栓塞性卒中的病因
J Stroke. 2024 Sep;26(3):349-359. doi: 10.5853/jos.2024.02670. Epub 2024 Sep 30.
6
The Role of Echocardiography in the Assessment of the Interatrial Septum and Patent Foramen Ovale as an Emboligenic Source.超声心动图在评估房间隔及卵圆孔未闭作为栓子来源中的作用
Arq Bras Cardiol. 2023 Oct;120(9):e20220903. doi: 10.36660/abc.20220903.
7
Noninvasive Neuromonitoring Modalities in Children Part I: Pupillometry, Near-Infrared Spectroscopy, and Transcranial Doppler Ultrasonography.儿童无创神经监测方式 第一部分：瞳孔测量法、近红外光谱法和经颅多普勒超声检查法
Neurocrit Care. 2024 Feb;40(1):130-146. doi: 10.1007/s12028-023-01730-4. Epub 2023 May 9.
8
White Matter Lesions Predominantly Located in Deep White Matter Represent Embolic Etiology Rather Than Small Vessel Disease.主要位于深部白质的白质病变代表栓塞病因而非小血管疾病。
Dement Neurocogn Disord. 2023 Jan;22(1):28-42. doi: 10.12779/dnd.2023.22.1.28. Epub 2013 Feb 3.
9
Simultaneous monitoring of the middle cerebral and basilar arteries to detect right-to-left shunts using transcranial Doppler by agitated saline administration.通过经颅多普勒超声（TCD），在注射生理盐水后同时监测大脑中动脉和基底动脉，以检测右向左分流。
Sci Rep. 2022 Apr 22;12(1):6658. doi: 10.1038/s41598-022-10645-7.
10
Clinical analysis of 33 cases with neonatal cerebral infarction.33例新生儿脑梗死的临床分析
Pak J Med Sci. 2021 Nov-Dec;37(7):1800-1807. doi: 10.12669/pjms.37.7.4720.
Stroke. 2015 Feb;46(2):e35-7. doi: 10.1161/STROKEAHA.114.007772. Epub 2015 Jan 13.
4
Interictal cerebral and systemic endothelial dysfunction in patients with migraine: a case-control study.偏头痛患者发作间期的脑和全身内皮功能障碍：病例对照研究。
J Neurol Neurosurg Psychiatry. 2015 Nov;86(11):1253-7. doi: 10.1136/jnnp-2014-309571. Epub 2014 Dec 30.
5
Patent foramen ovale treatment strategy: an Italian large prospective study.卵圆孔未闭治疗策略：一项意大利大型前瞻性研究。
J Cardiovasc Med (Hagerstown). 2014 Oct;15(10):761-8. doi: 10.2459/JCM.0000000000000138.
6
Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.《卒中和短暂性脑缺血发作患者卒中预防指南：美国心脏协会/美国卒中协会医疗保健专业人员指南》。
Stroke. 2014 Jul;45(7):2160-236. doi: 10.1161/STR.0000000000000024. Epub 2014 May 1.
7
Embolic strokes of undetermined source: the case for a new clinical construct.不明来源栓塞性脑卒中：一个新的临床概念。
Lancet Neurol. 2014 Apr;13(4):429-38. doi: 10.1016/S1474-4422(13)70310-7.
8
Systematic review of percutaneous closure versus medical therapy in patients with cryptogenic stroke and patent foramen ovale.隐源性卒中合并卵圆孔未闭患者经皮封堵与药物治疗的系统评价
BMJ Open. 2014 Mar 7;4(3):e004282. doi: 10.1136/bmjopen-2013-004282.
9
Evaluation of cryptogenic stroke with advanced diagnostic techniques.采用先进诊断技术对隐源性卒中进行评估。
Stroke. 2014 Apr;45(4):1186-94. doi: 10.1161/STROKEAHA.113.003720. Epub 2014 Feb 27.
10
Closure of patent foramen ovale in cryptogenic stroke: a never ending story.卵圆孔未闭封堵术治疗隐源性卒中：一个永无止境的故事。
Curr Opin Neurol. 2014 Feb;27(1):13-9. doi: 10.1097/WCO.0000000000000052.