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源自海洋真菌西氏双歧霉的β-淀粉样蛋白42降低剂。

Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii.

作者信息

Harms Henrik, Kehraus Stefan, Nesaei-Mosaferan Damun, Hufendieck Peter, Meijer Laurent, König Gabriele M

机构信息

Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.

ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, France.

出版信息

Steroids. 2015 Dec;104:182-8. doi: 10.1016/j.steroids.2015.09.012. Epub 2015 Oct 9.

DOI:10.1016/j.steroids.2015.09.012
PMID:26440473
Abstract

The ascomycete Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. Three new steroids (1-3), two of which are present as glycosides, with an untypical pattern of carbon-carbon double bounds, were obtained from fungal extracts, as well as the known xanthocillin X dimethyl ether (4). Compounds 2 and 4 were evaluated in an Alzheimer's disease cellular assay and found capable of preventing the enhanced production of amyloid β-42 in Aftin-5 treated cells. Aβ-42 lowering agents are considered as candidates for the treatment of neurodegenerative Alzheimer's disease.

摘要

子囊菌Dichotomomyces cejpii是从海洋海绵Callyspongia cf. C. flammea中分离得到的。从真菌提取物中获得了三种新的甾体化合物（1 - 3），其中两种以糖苷形式存在，具有不典型的碳 - 碳双键模式，还得到了已知的黄青霉素X二甲醚（4）。化合物2和4在阿尔茨海默病细胞试验中进行了评估，发现它们能够阻止在Aftin - 5处理的细胞中淀粉样β - 42的过量产生。降低Aβ - 42的药物被认为是治疗神经退行性阿尔茨海默病的候选药物。

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