Chaix Amandine, Zarrinpar Amir
Regulatory Biology Laboratory; The Salk Institute for Biological Studies ; La Jolla, CA, USA.
Regulatory Biology Laboratory; The Salk Institute for Biological Studies ; La Jolla, CA, USA ; Division of Gastroenterology; University of California ; San Diego; La Jolla, CA, USA.
Adipocyte. 2015 Apr 20;4(4):319-24. doi: 10.1080/21623945.2015.1025184. eCollection 2015 Oct-Dec.
Maintaining natural feeding rhythms with time-restricted feeding (TRF), without altering nutritional intake, prevents and reverses diet-induced obesity (DIO) and its associated metabolic disorders in mice. TRF has a direct effect on animal adiposity, causes an alteration of adipokine signaling, and diminishes white adipose tissue inflammation. Many genes involved in lipid metabolism are normally circadian, but their expression is perturbed with DIO; TRF restores their cyclical expression. One mechanism through which TRF could affect host metabolism is by altering the gut microbiome. Changes in the gut microbiome are coupled with an altered stool bile acid profile. Hence, TRF could affect lipid metabolism by altering bile acid signaling. TRF introduces many new possibilities in treating obesity and its associated metabolic disorders. However, further studies are needed to show whether these physiological findings in mice translate to humans.
通过限时进食(TRF)维持自然进食节律,在不改变营养摄入量的情况下,可预防和逆转小鼠饮食诱导的肥胖(DIO)及其相关代谢紊乱。TRF对动物肥胖有直接影响,会导致脂肪因子信号改变,并减轻白色脂肪组织炎症。许多参与脂质代谢的基因通常具有昼夜节律,但它们的表达会因DIO而受到干扰;TRF可恢复其周期性表达。TRF影响宿主代谢的一种机制可能是通过改变肠道微生物群。肠道微生物群的变化与粪便胆汁酸谱的改变相关。因此,TRF可能通过改变胆汁酸信号来影响脂质代谢。TRF为治疗肥胖及其相关代谢紊乱带来了许多新的可能性。然而,还需要进一步研究来证明小鼠的这些生理发现是否适用于人类。