细菌感染中耐药性演变的临床管理：案例研究。
Clinical management of resistance evolution in a bacterial infection: A case study.
机构信息
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Department of Biology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park PA 16802, USA Department of Entomology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park PA 16802, USA.
出版信息
Evol Med Public Health. 2015 Oct 10;2015(1):281-8. doi: 10.1093/emph/eov025.
We report the case of a patient with a chronic bacterial infection that could not be cured. Drug treatment became progressively less effective due to antibiotic resistance, and the patient died, in effect from overwhelming evolution. Even though the evolution of drug resistance was recognized as a major threat, and the fundamentals of drug resistance evolution are well understood, it was impossible to make evidence-based decisions about the evolutionary risks associated with the various treatment options. We present this case to illustrate the urgent need for translational research in the evolutionary medicine of antibiotic resistance.
我们报告了一例慢性细菌性感染患者的病例，该患者的疾病无法治愈。由于抗生素耐药性，药物治疗的效果逐渐降低，患者最终因进化压力过大而死亡。尽管耐药性的进化已被认为是一个主要威胁，并且耐药性进化的基本原理也被很好地理解，但仍然不可能就各种治疗方案相关的进化风险做出基于证据的决策。我们呈现这个病例是为了说明在抗生素耐药性的进化医学中转译研究的迫切需要。
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