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应对抗生素耐药性:环境框架。

Tackling antibiotic resistance: the environmental framework.

机构信息

1] Institute for Hydrobiology, Technische Universität Dresden, Dresden 01062, Germany. [2].

1] Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital, Apartado 2511, Porto 4202-401, Portugal. [2].

出版信息

Nat Rev Microbiol. 2015 May;13(5):310-7. doi: 10.1038/nrmicro3439. Epub 2015 Mar 30.

DOI:10.1038/nrmicro3439
PMID:25817583
Abstract

Antibiotic resistance is a threat to human and animal health worldwide, and key measures are required to reduce the risks posed by antibiotic resistance genes that occur in the environment. These measures include the identification of critical points of control, the development of reliable surveillance and risk assessment procedures, and the implementation of technological solutions that can prevent environmental contamination with antibiotic resistant bacteria and genes. In this Opinion article, we discuss the main knowledge gaps, the future research needs and the policy and management options that should be prioritized to tackle antibiotic resistance in the environment.

摘要

抗生素耐药性是对全球人类和动物健康的威胁,需要采取关键措施来降低环境中存在的抗生素耐药基因带来的风险。这些措施包括确定控制的关键点,开发可靠的监测和风险评估程序,以及实施能够防止抗生素耐药细菌和基因污染环境的技术解决方案。在这篇观点文章中,我们讨论了主要的知识空白、未来的研究需求以及应该优先考虑的政策和管理选择,以应对环境中的抗生素耐药性问题。

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Mathematical modeling of bacterial kinetics to predict the impact of antibiotic colonic exposure and treatment duration on the amount of resistant enterobacteria excreted.细菌动力学的数学模型,用于预测抗生素结肠暴露和治疗持续时间对排出的耐药肠杆菌数量的影响。
PLoS Comput Biol. 2014 Sep 11;10(9):e1003840. doi: 10.1371/journal.pcbi.1003840. eCollection 2014 Sep.
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High throughput profiling of antibiotic resistance genes in urban park soils with reclaimed water irrigation.
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Glob Health Action. 2025 Dec;18(1):2543101. doi: 10.1080/16549716.2025.2543101. Epub 2025 Aug 28.
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A Practical Framework for Environmental Antibiotic Resistance Monitoring in Freshwater Ecosystems.淡水生态系统中环境抗生素耐药性监测的实用框架
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