Li Xinhong, Li Kai, Wu Zhongjun
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China.
Department of General Medicine, Baotou Tumor Hospital Baotou 014000, China.
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9560-6. eCollection 2015.
We conducted a case-control study to investigate genetic variants of miR-146a rs2910164, miR-196a2 rs11614913, miR-149 rs2292832 and miR-499 rs3746444 in the development of HCC in a Chinese population. This case-control study included 266 HCC patients and 266 control subjects between January 2012 and December 2013. Conditional logistical regression analysis indicated that TT genotype and T allele of miR-196a2 rs11614913 carried a 2.29-fold (95% CI = 1.30-4.05) and 1.60-fold (95% CI = 1.11-2.32) increased risk of HCC when compared with CC genotype, respectively. The subgroup analysis indicated that the effect of miR-196a2 rs11614913 polymorphism was influence by HBV infection. HBV infection subjects carrying the CT + TT genotype of miR-196a2 rs11614913 had an increased risk of HCC, and the OR (95% CI) was 2.89 (1.19-7.02). In conclusion, miR-196a2 rs11614913 polymorphism may contribute to identifying individuals, especially in HBV-infected subjects, who are at high risk for HCC.
我们开展了一项病例对照研究，以调查中国人群中miR-146a rs2910164、miR-196a2 rs11614913、miR-149 rs2292832和miR-499 rs3746444的基因变异在肝癌发生发展中的作用。这项病例对照研究纳入了2012年1月至2013年12月期间的266例肝癌患者和266例对照者。条件logistic回归分析表明，与CC基因型相比，miR-196a2 rs11614913的TT基因型和T等位基因使肝癌风险分别增加2.29倍（95%CI = 1.30 - 4.05）和1.60倍（95%CI = 1.11 - 2.32）。亚组分析表明，miR-196a2 rs11614913多态性的作用受乙肝病毒感染影响。携带miR-196a2 rs11614913的CT + TT基因型的乙肝病毒感染受试者患肝癌的风险增加，OR（95%CI）为2.89（1.19 - 7.02）。总之，miR-196a2 rs11614913多态性可能有助于识别尤其是乙肝病毒感染受试者中患肝癌风险高的个体。
