Creuzot-Garcher Catherine, Binquet Christine, Daniel Sandrine, Bretillon Lionel, Acar Nyiazi, de Lazzer Aurélie, Arnould Laurent, Tzourio Christophe, Bron Alain M, Delcourt Cécile
Department of Ophthalmology, University Hospital, Dijon, France.
INRA, UMR1324 Center for Taste and Feeding Behavior, Dijon, France.
Acta Ophthalmol. 2016 Mar;94(2):e90-7. doi: 10.1111/aos.12842. Epub 2015 Oct 15.
To describe the design of the Montrachet Study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) and to report visual acuity and refractive errors in this elderly population.
Participants were recruited in Dijon (France), from the ongoing population-based 3C Study. In 2009-2011, 1153 participants from the 3 Cities Study, aged 75 years or more, had an initial eye examination and were scheduled for eye examinations. The eye examination comprised visual acuity, refraction, visual field, ocular surface assessment, photographs and OCT of the macula and the optic disc, measurement of intra-ocular pressure, central corneal thickness and macular pigment assessment. Information on cardiovascular and neurologic diseases and a large comprehensive database (blood samples, genetic testing, cognitive tests, MRI) were available from the 3C Study.
Presenting visual acuity <20/60 in the better eye was found in 2.3% (95% CI 1.5-3.2) of the participants with no gender differences. Visual impairment increased with age from 1.5% (95% CI 0.3-2.7) for those aged 75-79 years to 5.6% (95% CI 2.9-8.4) for patients 85 years and older (p = 0.0003). Spherical equivalent did not differ between men and women (p = 0.8) and decreased with age whatever the lens status.
Despite the high prevalence of self-reported eye diseases in this elderly population, visual impairment was low and increased with age. The Montrachet Study may help to better estimate the prevalence of eye diseases in people over 75 years of age and to seek associations with cardiovascular and neurologic diseases and their potential risk factors.
描述蒙特拉谢研究（黄斑病变、视神经营养、神经血管和心脏疾病研究）的设计，并报告该老年人群的视力和屈光不正情况。
参与者从法国第戎正在进行的基于人群的3C研究中招募。在2009年至2011年期间，来自三城市研究的1153名年龄在75岁及以上的参与者进行了初次眼部检查，并安排了后续眼部检查。眼部检查包括视力、验光、视野、眼表评估、黄斑和视盘的照片及光学相干断层扫描（OCT）、眼压测量、中央角膜厚度测量和黄斑色素评估。3C研究提供了心血管和神经系统疾病的信息以及一个大型综合数据库（血液样本、基因检测、认知测试、磁共振成像）。
在参与者中，较好眼的视力<20/60的比例为2.3%（95%可信区间1.5 - 3.2），无性别差异。视力损害随年龄增加，75 - 79岁人群中为1.5%（95%可信区间0.3 - 2.7），85岁及以上患者中为5.6%（95%可信区间2.9 - 8.4）（p = 0.0003）。等效球镜度在男性和女性之间无差异（p = 0.8），且无论晶状体状态如何，均随年龄下降。
尽管该老年人群中自我报告的眼部疾病患病率较高，但视力损害较低且随年龄增加。蒙特拉谢研究可能有助于更好地估计75岁以上人群中眼部疾病的患病率，并寻找与心血管和神经系统疾病及其潜在危险因素的关联。
