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西红花苷和氯化锌对链脲佐菌素诱导的糖尿病大鼠血液锌水平及代谢和氧化参数的影响

Effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in streptozotocin-induced diabetic rats.

作者信息

Asri-Rezaei Siamak, Tamaddonfard Esmaeal, Ghasemsoltani-Momtaz Behnaz, Erfanparast Amir, Gholamalipour Sima

机构信息

Division of Clinical Pathology, Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

出版信息

Avicenna J Phytomed. 2015 Sep-Oct;5(5):403-12.

PMID:26468459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4599111/
Abstract

OBJECTIVES

Crocin is one of constituents of saffron and has antioxidant property. Zinc chloride is one of the common compounds of zinc with antioxidant activity. The present study was aimed to investigate separate and combined treatment effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in diabetic rats.

MATERIALS AND METHODS

Diabetes was induced by intraperitoneal (i.p.) injection of 50 mg/kg of streptozotocin (STZ) and was confirmed by blood glucose levels higher than 250 mg/dL. After confirmation of diabetes, injections (i.p.) of crocin and zinc chloride were performed for six weeks. At the end of the experiment, blood levels of zinc, glucose, insulin, malodialdehyde (MDA), and total antioxidant capacity (TAC) were measured. ‎.

RESULTS

Crocin (25 and 50 mg/kg) and zinc chloride (5 mg/kg) significantly recovered the decreased levels of zinc, insulin, and TAC and improved the increased levels of glucose and MDA in STZ-induced diabetic rats. In a combination treatment performed with an ineffective dose of crocin (12.5 mg/kg) and a low dose of zinc chloride (1.25 mg/kg), improving effects were observed on the above-mentioned biochemical parameters.‎.

CONCLUSION

The results indicated that separate and combined treatments with crocin and zinc chloride produced improving effects on the blood levels of zinc, glucose, insulin, MDA and TAC in STZ-induced diabetic rats.

摘要

目的

西红花苷是藏红花的成分之一，具有抗氧化特性。氯化锌是锌的常见化合物之一，具有抗氧化活性。本研究旨在探讨西红花苷和氯化锌单独及联合治疗对糖尿病大鼠血液锌水平、代谢和氧化参数的影响。

材料与方法

通过腹腔注射50mg/kg链脲佐菌素（STZ）诱导糖尿病，并通过血糖水平高于250mg/dL进行确认。糖尿病确诊后，腹腔注射西红花苷和氯化锌，持续六周。实验结束时，测量血液中的锌、葡萄糖、胰岛素、丙二醛（MDA）和总抗氧化能力（TAC）水平。

结果

西红花苷（25mg/kg和50mg/kg）和氯化锌（5mg/kg）显著恢复了STZ诱导的糖尿病大鼠中降低的锌、胰岛素和TAC水平，并改善了升高的葡萄糖和MDA水平。在用无效剂量的西红花苷（12.5mg/kg）和低剂量的氯化锌（1.25mg/kg）进行联合治疗时，观察到对上述生化参数有改善作用。

结论

结果表明，西红花苷和氯化锌单独及联合治疗对STZ诱导的糖尿病大鼠血液中的锌、葡萄糖、胰岛素、MDA和TAC水平产生了改善作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/ce5cefb52eff/AJP-5-403-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/1e0c3c90b8d6/AJP-5-403-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/bd349721402b/AJP-5-403-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/978620eba570/AJP-5-403-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/5c5a389a8ec0/AJP-5-403-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/ce5cefb52eff/AJP-5-403-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/1e0c3c90b8d6/AJP-5-403-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/bd349721402b/AJP-5-403-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/978620eba570/AJP-5-403-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/5c5a389a8ec0/AJP-5-403-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b39/4599111/ce5cefb52eff/AJP-5-403-g005.jpg

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