基于自组装蛋白纳米颗粒的疟疾疫苗。
Malaria vaccine based on self-assembling protein nanoparticles.
作者信息
Burkhard Peter, Lanar David E
机构信息
a Institute of Materials, Science and Department of Molecular and Cell Biology , University of Connecticut , Storrs , CT 06269 , USA.
b Malaria Vaccine Branch , Walter Reed Army Institute of Research , Silver Spring , MD 20910 , USA.
出版信息
Expert Rev Vaccines. 2015;14(12):1525-7. doi: 10.1586/14760584.2015.1096781. Epub 2015 Oct 15.
Abstract
Despite recent progress with GSK's RTS,S malaria vaccine, there remains a desperate need for an efficient malaria vaccine. We have used a repetitive antigen display technology to display malaria specific B cell and T cell epitopes in an effort to design a vaccine against Plasmodium falciparum malaria. Our protein sequence when assembled into a nanoparticle induces strong, long-lived and protective immune responses against infection with the parasite. We are confident that the clinical trials with our most developed vaccine candidate will show good protection in a controlled human malaria infection trial.
摘要
尽管葛兰素史克公司的RTS,S疟疾疫苗最近取得了进展，但仍然迫切需要一种高效的疟疾疫苗。我们使用了一种重复抗原展示技术来展示疟疾特异性B细胞和T细胞表位，以期设计一种针对恶性疟原虫疟疾的疫苗。我们的蛋白质序列组装成纳米颗粒后，能诱导针对该寄生虫感染产生强烈、持久且具有保护性的免疫反应。我们相信，对我们研发程度最高的候选疫苗进行的临床试验，将在受控人体疟疾感染试验中显示出良好的保护效果。
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