Sharp N J, Sullivan M
Veterinary Hospital, University of Liverpool, UK.
J Am Vet Med Assoc. 1989 Mar 15;194(6):782-6.
Fifteen dogs with nasal aspergillosis were treated with ketoconazole (5 mg/kg of body weight, q 12 h, PO) for 2 to 18 weeks. Four dogs whose conditions deteriorated during treatment received ketoconazole for less than the prescribed 6 weeks. Six months or more later, only 47% of the dogs were determined to be disease-free, on the basis of no fungal growth on culture. It was concluded that ketoconazole at this dosage is a useful treatment for canine nasal aspergillosis, but is no more effective than thiabendazole.
15只患有鼻曲霉病的犬接受酮康唑治疗（5毫克/千克体重，每12小时口服一次），持续2至18周。4只在治疗期间病情恶化的犬接受酮康唑治疗的时间少于规定的6周。6个月或更长时间后，根据培养物中无真菌生长情况，只有47%的犬被判定为无病。得出的结论是，这种剂量的酮康唑是治疗犬鼻曲霉病的一种有效疗法，但并不比噻苯达唑更有效。
