Gasdermin D：期待已久的细胞焦亡执行者。
Gasdermin D: the long-awaited executioner of pyroptosis.
作者信息
Man Si Ming, Kanneganti Thirumala-Devi
机构信息
Department of Immunology, St. Jude Children's Research Hospital, MS #351, 262 Danny Thomas Place, Memphis, TN 38105, USA.
出版信息
Cell Res. 2015 Nov;25(11):1183-4. doi: 10.1038/cr.2015.124. Epub 2015 Oct 20.
Abstract
Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.
摘要
炎症性半胱天冬酶可驱动一种称为细胞焦亡的溶解性细胞死亡形式，以应对微生物感染和内源性损伤相关信号。现在有两项研究表明，炎症性半胱天冬酶对底物gasdermin D的切割必然导致细胞最终发生焦亡。
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