一种可注射的硅酸钙基根管封闭剂的物理性质和生物相容性：体外和体内研究
Physical properties and biocompatibility of an injectable calcium-silicate-based root canal sealer: in vitro and in vivo study.
作者信息
Lim Eun-Su, Park Young-Bae, Kwon Young-Sun, Shon Won-Jun, Lee Kwang-Won, Min Kyung-San
机构信息
Department of Conservative Dentistry, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, 567 Baekje-daero, Jeonju-si, 54896, Korea.
Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, 20 Geonji-ro, 54907, Jeonju-si, Korea.
出版信息
BMC Oral Health. 2015 Oct 21;15(1):129. doi: 10.1186/s12903-015-0112-9.
BACKGROUND
The aim of this study was to investigate the physical properties and biological effects of an experimentally developed injectable premixed calcium-silicate root canal sealer (Endoseal) in comparison with mineral trioxide aggregate (MTA) and a resin-based sealer (AHplus).
METHODS
The pH, solubility, dimensional change, flow, and radiopacity of the materials were evaluated. Biocompatibility was evaluated on the basis of cell morphology and a viability test using MC3T3-E1 cells. For evaluate inflammatory reaction, the tested sealers were implanted into dorsal subcutaneous connective tissue of Sprague Dawley rats. After 7 days, the implants with the surrounding tissue were retrieved, and histological evaluation was performed.
RESULTS
Endoseal showed high alkalinity similar to that of MTA. The solubility of the tested materials was similar. The dimensional change and flow of Endoseal was significantly higher than that of other materials (P < 0.05). The radiopacity of Endoseal was lower than that of AHplus (P < 0.05). The biocompatibility was similar to those of MTA. Inflammatory reaction of Endoseal was similar with that of MTA, but lower than that of AHplus (P < 0.05).
CONCLUSIONS
The present study indicates that Endoseal has favorable physical properties and biocompatibility. Therefore, we suggest that Endoseal has the potential to be used as a predictable root canal sealer.
背景
本研究旨在对比实验研发的可注射预混硅酸钙根管封闭剂（Endoseal）与三氧化矿物凝聚体（MTA）和树脂基封闭剂（AHplus）的物理性能和生物学效应。
方法
评估材料的pH值、溶解度、尺寸变化、流动性和射线不透性。基于细胞形态和使用MC3T3-E1细胞的活力测试评估生物相容性。为评估炎症反应，将测试的封闭剂植入Sprague Dawley大鼠的背部皮下结缔组织。7天后，取出植入物及其周围组织并进行组织学评估。
结果
Endoseal显示出与MTA相似的高碱性。测试材料的溶解度相似。Endoseal的尺寸变化和流动性显著高于其他材料（P < 0.05）。Endoseal的射线不透性低于AHplus（P < 0.05）。生物相容性与MTA相似。Endoseal的炎症反应与MTA相似，但低于AHplus（P < 0.05）。
结论
本研究表明Endoseal具有良好的物理性能和生物相容性。因此，我们认为Endoseal有潜力用作一种可预测的根管封闭剂。
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