Malta Cristiana Pereira, Santi Samantha Simoni, Barcelos Raquel Cristine Silva, Zanatta Fabrício Batistin, Bier Carlos Alexandre Souza, Morgental Renata Dornelles
Department of Stomatology, School of Dentistry, Federal University of Santa Maria, Santa Maria, Brazil.
J Conserv Dent Endod. 2024 Apr;27(4):345-359. doi: 10.4103/JCDE.JCDE_24_24. Epub 2024 Apr 5.
The aim was to determine whether premixed calcium silicate-based root canal sealers have better biological properties than AH Plus.
Searches of studies published up to January 2023 were performed in the PubMed/MEDLINE and EMBASE and via other methods (databases of the International Endodontic Journal, Journal of Endodontics, and gray literature). The inclusion criteria were animal and studies that analyzed the response in the dorsal subcutaneous tissue of rats, cell viability, and genotoxicity. Systematic Review Centre for Laboratory Animal Experimentation Risk of Bias (RoB) tool for studies and modified CONSORT checklist for were appraised. Meta-analysis was performed using the Stata.
Fifty-two studies were included. In the RoB, studies fulfilled 20%-50% of the items and 60%-100%. The studies included in the meta-analysis demonstrated better histocompatibility with the premixed calcium silicate-based sealers at 30 days and greater cell viability with these sealers when used in undiluted extracts in experimental period of 72 h and in extracts with 1:2 and 1:4 dilution in 24 and 72 h. In contrast, no difference between materials was found concerning genotoxicity.
Premixed calcium silicate-based root canal sealers have better histocompatibility and are less cytotoxic than the epoxy resin-based sealer AH Plus, demonstrating favorable biological behavior.
旨在确定预混硅酸钙基根管封闭剂是否比AH Plus具有更好的生物学性能。
检索截至2023年1月发表的研究，检索数据库包括PubMed/MEDLINE、EMBASE，并通过其他方法（国际牙髓病学杂志、牙髓病学杂志数据库及灰色文献）进行检索。纳入标准为动物研究以及分析大鼠背部皮下组织反应、细胞活力和遗传毒性的研究。使用实验室动物实验偏倚风险（RoB）工具对研究进行评估，并对随机对照试验使用改良的CONSORT清单进行评估。使用Stata进行荟萃分析。
共纳入52项研究。在偏倚风险评估中，部分研究满足20%-50%的条目，部分研究满足60%-100%。荟萃分析纳入的研究表明，预混硅酸钙基封闭剂在30天时具有更好的组织相容性，在72小时实验期的未稀释提取物以及24小时和72小时1:2和1:4稀释的提取物中使用时，这些封闭剂具有更高的细胞活力。相比之下，在遗传毒性方面未发现材料之间存在差异。
预混硅酸钙基根管封闭剂比环氧树脂基封闭剂AH Plus具有更好的组织相容性，细胞毒性更小，表现出良好的生物学行为。
