Guo Feng, Xie Yuliang, Li Sixing, Lata James, Ren Liqiang, Mao Zhangming, Ren Baiyang, Wu Mengxi, Ozcelik Adem, Huang Tony Jun
Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
Lab Chip. 2015 Dec 21;15(24):4517-23. doi: 10.1039/c5lc01049g. Epub 2015 Oct 28.
We demonstrate acoustic tweezers used for disposable devices. Rather than forming an acoustic resonance, we locally transmitted standing surface acoustic waves into a removable, independent polydimethylsiloxane (PDMS)-glass hybridized microfluidic superstrate device for micromanipulation. By configuring and regulating the displacement nodes on a piezoelectric substrate, cells and particles were effectively patterned and transported into said superstrate, accordingly. With the label-free and contactless nature of acoustic waves, the presented technology could offer a simple, accurate, low-cost, biocompatible, and disposable method for applications in the fields of point-of-care diagnostics and fundamental biomedical studies.
我们展示了用于一次性设备的声镊。我们并非形成声共振,而是将驻表面声波局部传输到一个可移除的、独立的聚二甲基硅氧烷(PDMS)-玻璃杂交微流控上层器件中,以进行微操作。通过在压电基板上配置和调节位移节点,细胞和颗粒被有效地图案化并相应地传输到所述上层器件中。由于声波具有无标记和非接触的特性,所提出的技术可为即时诊断和基础生物医学研究领域的应用提供一种简单、准确、低成本、生物相容且一次性的方法。