丝状支原体丝状亚种挑战菌株阿法德（Afadé）和B237的高质量基因组草图。
High quality draft genomes of the Mycoplasma mycoides subsp. mycoides challenge strains Afadé and B237.
作者信息
Fischer Anne, Santana-Cruz Ivette, Hegerman Jan, Gourlé Hadrien, Schieck Elise, Lambert Mathieu, Nadendla Suvarna, Wesonga Hezron, Miller Rachel A, Vashee Sanjay, Weber Johann, Meens Jochen, Frey Joachim, Jores Joerg
机构信息
International Livestock Research Institute, PO Box 30709, 00100 Nairobi, Kenya ; International Centre for Insect Physiology and Ecology, PO Box 30772, 00100 Nairobi, Kenya.
Institute for Genome Sciences, University of Maryland School of Medicine, 801 W. Baltimore Street BioPark II, 21201 Baltimore, MD USA.
出版信息
Stand Genomic Sci. 2015 Oct 29;10:89. doi: 10.1186/s40793-015-0067-0. eCollection 2015.
Members of the Mycoplasma mycoides cluster' represent important livestock pathogens worldwide. Mycoplasma mycoides subsp. mycoides is the etiologic agent of contagious bovine pleuropneumonia (CBPP), which is still endemic in many parts of Africa. We report the genome sequences and annotation of two frequently used challenge strains of Mycoplasma mycoides subsp. mycoides, Afadé and B237. The information provided will enable downstream 'omics' applications such as proteomics, transcriptomics and reverse vaccinology approaches. Despite the absence of Mycoplasma pneumoniae like cyto-adhesion encoding genes, the two strains showed the presence of protrusions. This phenotype is likely encoded by another set of genes.
丝状支原体簇的成员是全球重要的家畜病原体。丝状支原体丝状亚种是牛传染性胸膜肺炎（CBPP）的病原体，该病在非洲许多地区仍然流行。我们报告了丝状支原体丝状亚种的两种常用攻毒菌株Afadé和B237的基因组序列及注释。所提供的信息将有助于开展蛋白质组学、转录组学和反向疫苗学方法等下游“组学”应用。尽管这两种菌株缺乏肺炎支原体样的细胞黏附编码基因，但它们显示出有突起。这种表型可能由另一组基因编码。
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