匹兹堡心血管健康研究-认知研究长期随访中的痴呆症和死亡风险
Risk of dementia and death in the long-term follow-up of the Pittsburgh Cardiovascular Health Study-Cognition Study.
作者信息
Kuller Lewis H, Lopez Oscar L, Becker James T, Chang Yuefang, Newman Anne B
机构信息
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Alzheimers Dement. 2016 Feb;12(2):170-183. doi: 10.1016/j.jalz.2015.08.165. Epub 2015 Oct 28.
INTRODUCTION
Increasing life expectancy has resulted in a larger population of older individuals at risk of dementia.
METHODS
The Cardiovascular Health Study-Cognition Study followed 532 participants from 1998-99 (mean age 79) to 2013 (mean age 93) for death and dementia.
RESULTS
Risk of death was determined by extent of coronary artery calcium, high-sensitivity cardiac troponin, brain natriuretic peptide, and white matter grade. Significant predictors of dementia were age, apolipoprotein-E4, vocabulary raw score, hippocampal volume, ventricular size, cognitive performance, and number of blocks walked. By 2013, 160 of 532 were alive, including 19 cognitively normal. Those with normal cognition had higher grade education, better cognition test scores, greater hippocampal volume, faster gait speed, and number of blocks walked as compared with survivors who were demented.
DISCUSSION
Few survived free of dementia and disability. Prevention and delay of cognitive decline for this older population is an imperative.
引言
预期寿命的增加导致患痴呆症风险的老年人口增多。
方法
心血管健康研究-认知研究对532名参与者从1998 - 1999年（平均年龄79岁）至2013年（平均年龄93岁）进行了死亡和痴呆情况的跟踪。
结果
死亡风险由冠状动脉钙化程度、高敏心肌肌钙蛋白、脑钠肽和白质等级决定。痴呆的显著预测因素包括年龄、载脂蛋白E4、词汇原始分数、海马体体积、脑室大小、认知表现和行走的街区数。到2013年，532名参与者中有160人存活，其中19人认知正常。与痴呆的幸存者相比，认知正常者受教育程度更高、认知测试分数更好、海马体体积更大、步态速度更快且行走的街区数更多。
讨论
很少有人能在无痴呆和残疾的情况下存活。对这一年龄较大的人群预防和延缓认知衰退势在必行。
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