Yang Jie, Hu Shaomin, Zhao Luming, Kaplan Daniel H, Perdew Gary H, Xiong Na
Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
Nat Immunol. 2016 Jan;17(1):48-56. doi: 10.1038/ni.3312. Epub 2015 Nov 2.
Innate lymphoid cells (ILCs) 'preferentially' localize into barrier tissues, where they function in tissue protection but can also contribute to inflammatory diseases. The mechanisms that regulate the establishment of ILCs in barrier tissues are poorly understood. Here we found that under steady-state conditions, ILCs in skin-draining lymph nodes (sLNs) were continuously activated to acquire regulatory properties and high expression of the chemokine receptor CCR10 for localization into the skin. CCR10(+) ILCs promoted the homeostasis of skin-resident T cells and, reciprocally, their establishment in the skin required T cell-regulated homeostatic environments. CD207(+) dendritic cells expressing the transcription factor Foxn1 were required for the proper generation of CCR10(+) ILCs. These observations reveal mechanisms that underlie the specific programming and priming of skin-homing CCR10(+) ILCs in the sLNs.
固有淋巴细胞（ILCs）“优先”定位于屏障组织，在那里它们发挥组织保护作用，但也可能导致炎症性疾病。调节ILCs在屏障组织中建立的机制尚不清楚。在这里，我们发现，在稳态条件下，皮肤引流淋巴结（sLNs）中的ILCs持续被激活，以获得调节特性和趋化因子受体CCR10的高表达，从而定位于皮肤。CCR10(+) ILCs促进皮肤驻留T细胞的稳态，相反，它们在皮肤中的建立需要T细胞调节的稳态环境。表达转录因子Foxn1的CD207(+)树突状细胞是正确生成CCR10(+) ILCs所必需的。这些观察结果揭示了sLNs中皮肤归巢CCR10(+) ILCs的特定编程和启动的潜在机制。
