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Recognition of Immune Response for the Early Diagnosis and Treatment of Osteoarthritis.免疫反应在骨关节炎早期诊断和治疗中的认识
J Immunol Res. 2015;2015:192415. doi: 10.1155/2015/192415. Epub 2015 May 3.
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[Effects of physical factors on neck or shoulder pain and low back pain of adolescents].[物理因素对青少年颈肩痛和腰背痛的影响]
Zhonghua Yi Xue Za Zhi. 2014 Nov 25;94(43):3411-5.
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Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model.在一种利血平诱导的大鼠痛觉模型中，外周和脊髓的伤害感受机制。
Pain. 2015 Mar;156(3):415-427. doi: 10.1097/01.j.pain.0000460334.49525.5e.
4
The dichotomized role for acid sensing ion channels in musculoskeletal pain and inflammation.酸敏感离子通道在肌肉骨骼疼痛和炎症中的双重作用。
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5
ASIC3 Is Required for Development of Fatigue-Induced Hyperalgesia.ASIC3是疲劳诱导性痛觉过敏发展所必需的。
Mol Neurobiol. 2016 Mar;53(2):1020-1030. doi: 10.1007/s12035-014-9055-4. Epub 2015 Jan 11.
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酸敏感离子通道在肌肉骨骼疾病中介导疼痛和炎症。

ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases.

作者信息

Abdelhamid Ramy E, Sluka Kathleen A

机构信息

Department of Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa.

Department of Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa

出版信息

Physiology (Bethesda). 2015 Nov;30(6):449-59. doi: 10.1152/physiol.00030.2015.

DOI:10.1152/physiol.00030.2015
PMID:26525344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4747907/
Abstract

Chronic musculoskeletal pain is debilitating and affects ∼ 20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.

摘要

慢性肌肉骨骼疼痛使人虚弱，影响约20%的成年人。在类风湿关节炎等疼痛性肌肉骨骼疾病中存在组织酸中毒。酸敏感离子通道（ASICs）位于骨骼肌和关节伤害感受器以及肌肉和关节中的非神经元细胞上，在这些部位它们介导痛觉。本文综述了不同类型ASICs的特性、影响其pH敏感性的因素，以及它们在肌肉骨骼痛觉过敏和炎症中的作用。