Sarmiento Alvaro, Diaz-Castro Javier, Pulido-Moran Mario, Kajarabille Naroa, Guisado Rafael, Ochoa Julio J
Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada, Biomedical Research Centre, Health Sciences Technological Park, Avenida del Conocimiento s/n, Armilla, 18071 Granada, Spain.
Curr Drug Metab. 2016;17(4):345-58. doi: 10.2174/1389200216666151103115654.
Coenzyme Q10 (CoQ10) is an endogenous lipid-soluble benzoquinone compound that functions as a diffusible electron carrier in the electron transport chain. It is prevalent in all human tissues and organs, although it is mainly biosynthesised and concentrated in tissues with high energy turnover. The aim of this review was to perform an exhaustive analysis of the influence and effects of CoQ10 supplementation on parameters related to exercise in healthy humans, and to clarify the current state of knowledge of this field of study, presenting the relevant data in a systematic manner.
This paper describes a transversal descriptive systematic review of published research in this field; the study was conducted using a method adapted from the PRISMA guidelines. The inclusion criteria applied were based on the PICO (population, intervention, comparison, and outcome) model.
The database search performed yielded 372 citations. Finally, 13 studies met all the inclusion criteria and were incorporated in the present review.
CoQ10 has properties related to bioenergetic and antioxidant activity; thus, it is intimately involved in energy production and in the prevention of peroxidative damage to membrane phospholipids and of free radical-induced oxidation. These properties make it suitable as a dietary supplement to improve cellular bioenergetics and to inhibit certain age-related pathologies.
辅酶Q10（CoQ10）是一种内源性脂溶性苯醌化合物，在电子传递链中作为可扩散的电子载体发挥作用。它在人体所有组织和器官中都普遍存在，尽管它主要在能量转换率高的组织中进行生物合成并集中分布。本综述的目的是详尽分析补充CoQ10对健康人运动相关参数的影响和作用，阐明该研究领域的当前知识状态，并系统地呈现相关数据。
本文描述了对该领域已发表研究的横向描述性系统综述；该研究采用了改编自PRISMA指南的方法进行。所应用的纳入标准基于PICO（人群、干预措施、对照和结果）模型。
数据库检索共获得372条引文。最终，13项研究符合所有纳入标准并被纳入本综述。
CoQ10具有与生物能量和抗氧化活性相关的特性；因此，它密切参与能量产生以及预防膜磷脂的过氧化损伤和自由基诱导的氧化。这些特性使其适合作为膳食补充剂，以改善细胞生物能量学并抑制某些与年龄相关的病症。
