Toman Emma, Harrisson S, Belli T
Major Trauma Service, Queen Elizabeth Hospital, Birmingham, UK.
Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Birmingham, UK.
J R Army Med Corps. 2016 Apr;162(2):103-8. doi: 10.1136/jramc-2015-000517. Epub 2015 Nov 2.
Biomarkers allow physiological processes to be monitored, in both health and injury. Multiple attempts have been made to use biomarkers in traumatic brain injury (TBI). Identification of such biomarkers could allow improved understanding of the pathological processes involved in TBI, diagnosis, prognostication and development of novel therapies. This review article aims to cover both established and emerging TBI biomarkers along with their benefits and limitations. It then discusses the potential value of TBI biomarkers to military, civilian and sporting populations and the future hopes for developing a role for biomarkers in head injury management.
生物标志物能够对健康和损伤状态下的生理过程进行监测。人们已多次尝试将生物标志物用于创伤性脑损伤（TBI）。识别此类生物标志物有助于更好地理解TBI所涉及的病理过程、诊断、预后评估以及新型疗法的开发。这篇综述文章旨在涵盖已确立的和新出现的TBI生物标志物及其优缺点。随后讨论了TBI生物标志物对军事人员、平民和运动员群体的潜在价值，以及在头部损伤管理中发挥生物标志物作用的未来展望。
