Rivera-Huerta Marisol, Lizárraga-Grimes Vania Lorena, Castro-Torres Ibrahim Guillermo, Tinoco-Méndez Mabel, Macías-Rosales Lucía, Sánchez-Bartéz Francisco, Tapia-Pérez Graciela Guadalupe, Romero-Romero Laura, Gracia-Mora María Isabel
Unidad de Investigación Preclínica (UNIPREC), Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Colegio de Ciencias y Humanidades, Plantel Sur, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Biomed Res Int. 2017;2017:9758982. doi: 10.1155/2017/9758982. Epub 2017 Feb 15.
Inulin-type fructans are polymers of fructose molecules and are known for their capacity to enhance absorption of calcium and magnesium, to modulate gut microbiota and energy metabolism, and to improve glycemia. We evaluated and compared the effects of Chicory inulin "Synergy 1®" and inulin from Mexican agave "Metlin®" in two experimental models of colon cancer and bone calcium metabolism in mice and rats. Inulins inhibited the development of dextran sulfate sodium-induced colitis and colon cancer in mice; these fructans reduced the concentration of tumor necrosis factor alpha and prevented the formation of intestinal polyps, villous atrophy, and lymphoid hyperplasia. On the other hand, inulin treatments significantly increased bone densitometry (femur and vertebra) in ovariectomized rats without altering the concentration of many serum biochemical parameters and urinary parameters. Histopathology results were compared between different experimental groups. There were no apparent histological changes in rats treated with inulins and a mixture of inulins-isoflavones. Our results showed that inulin-type fructans have health-promoting properties related to enhanced calcium absorption, potential anticancer properties, and anti-inflammatory effects. The use of inulin as a prebiotic can improve health and prevent development of chronic diseases such as cancer and osteoporosis.
菊粉型果聚糖是果糖分子的聚合物，以其增强钙和镁吸收、调节肠道微生物群和能量代谢以及改善血糖水平的能力而闻名。我们在小鼠和大鼠的两种结肠癌和骨钙代谢实验模型中评估并比较了菊苣菊粉“Synergy 1®”和墨西哥龙舌兰菊粉“Metlin®”的效果。菊粉抑制了小鼠硫酸葡聚糖钠诱导的结肠炎和结肠癌的发展；这些果聚糖降低了肿瘤坏死因子α的浓度，并防止了肠息肉、绒毛萎缩和淋巴组织增生的形成。另一方面，菊粉处理显著增加了去卵巢大鼠的骨密度测量值（股骨和椎骨），而没有改变许多血清生化参数和尿液参数的浓度。比较了不同实验组之间的组织病理学结果。用菊粉和菊粉 - 异黄酮混合物处理的大鼠没有明显的组织学变化。我们的结果表明，菊粉型果聚糖具有促进健康的特性，与增强钙吸收、潜在的抗癌特性和抗炎作用有关。将菊粉用作益生元可以改善健康状况并预防癌症和骨质疏松症等慢性疾病的发展。
