Gul Waseem, Stamper Brandon J, Godfrey Murrell, ElSohly Mahmoud A
ElSohly Laboratories, Inc., 5 Industrial Park Drive, Oxford, MS 38655, USA National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.
ElSohly Laboratories, Inc., 5 Industrial Park Drive, Oxford, MS 38655, USA Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA.
J Anal Toxicol. 2016 Mar;40(2):124-32. doi: 10.1093/jat/bkv124. Epub 2015 Nov 4.
A method was developed for the analysis of amphetamines and cocaine (Coc) in wastewater samples using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS). Seven stimulant-type drugs and metabolites were analyzed. These drugs included amphetamine (Amp), methamphetamine (Meth), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), methylenedioxyethylamphetamine (MDEA), Coc and benzoylecgonine (BE, the major metabolite of Coc). These drugs were chosen because of their widespread use. Wastewater samples were collected at both the Oxford Waste Water Treatment Plant in Oxford, Mississippi (MS) and the University Wastewater Treatment Plant in University, MS. Samples were collected on weekends in which the Ole Miss Rebel football team held home games (Vaught-Hemingway Stadium, University, MS 38677). The collected samples were analyzed using a validated method and found to contain Amp, Meth, MDMA, Coc and BE. The concentrations of Amp and BE significantly rose in the university wastewater during football games.
开发了一种使用液相色谱-串联质谱法（LC-MS-MS）分析废水样品中苯丙胺类和可卡因（Coc）的方法。分析了七种兴奋剂类药物及其代谢物。这些药物包括苯丙胺（Amp）、甲基苯丙胺（Meth）、亚甲二氧基苯丙胺（MDA）、亚甲二氧基甲基苯丙胺（MDMA）、亚甲二氧基乙基苯丙胺（MDEA）、可卡因（Coc）和苯甲酰芽子碱（BE，可卡因的主要代谢物）。选择这些药物是因为它们的广泛使用。在密西西比州牛津市的牛津污水处理厂和密西西比州大学的大学污水处理厂采集了废水样品。在密西西比大学叛逆者橄榄球队举行主场比赛的周末（密西西比州大学沃思特-海明威体育场，邮编38677）采集样品。使用经过验证的方法对采集的样品进行分析，发现其中含有Amp、Meth、MDMA、Coc和BE。在橄榄球比赛期间，大学废水中Amp和BE的浓度显著上升。
