Department of Chemistry, Murray State University, Murray, KY, United States.
Department of Chemistry, Murray State University, Murray, KY, United States.
Sci Total Environ. 2021 Jan 15;752:141712. doi: 10.1016/j.scitotenv.2020.141712. Epub 2020 Aug 15.
High school sports gather a significantly larger number of fans than college and professional sports in the U.S. Adolescent and adult students in high schools and colleges (aged 12-25) are among the most vulnerable population to substance use. Event planners, risk managers, and emergency medical service personnel can extrapolate the mass loads of drugs in wastewater in this study to evaluate the spectator behavior in relatively larger basketball gatherings. Thirty-three illicit and prescribed psychotic drug residues (out of target 36) and five new psychoactive substances (NPS, out of target 40) were quantified in wastewater, using ultra-performance liquid chromatography and tandem mass spectrometry, discharged during a college and a high school basketball games that were played in the same stadium in Kentucky. The wastewater concentrations of amphetamine, methylphenidate, hydromorphone were significantly higher (p ≤ 0.040) during a high school basketball game whereas cocaine, hydrocodone, and gabapentin was significantly higher (p ≤ 0.006) in a college basketball game. Higher cocaine to its metabolite ratio suggested that a significant amount of cocaine may have directly discharged down the drain during the college basketball game. Two synthetic cathinones (methcathinone and 4-methyl pentedrone) and three other NPSs (4-ANPP, mCPP, and 4-methylamphetamine) were also quantified in wastewater indicate the prevalence of NPSs in Kentucky. This is the first report of quantified substances of potential abuses at basketball games.
在美国，高中体育比大学和职业体育吸引了更多的粉丝。青少年和大学生（12-25 岁）是最容易接触药物的人群之一。活动策划者、风险管理人员和紧急医疗服务人员可以从本研究中的污水中推断出大量药物负荷，以评估相对较大的篮球比赛中的观众行为。在肯塔基州的同一个体育场举行的一场大学和一场高中篮球比赛期间，使用超高效液相色谱和串联质谱法对污水中的 33 种非法和处方精神药物残留（目标 36 种中的 33 种）和 5 种新的精神活性物质（NPS，目标 40 种中的 5 种）进行了定量分析。污水中安非他命、哌甲酯、氢吗啡酮的浓度在高中篮球比赛期间明显更高（p≤0.040），而可卡因、氢可酮和加巴喷丁在大学篮球比赛期间明显更高（p≤0.006）。可卡因与其代谢物比值较高表明，在大学篮球比赛期间，相当数量的可卡因可能直接从污水管中排放。污水中还定量了两种合成卡西酮（甲卡西酮和 4-甲基戊酮）和三种其他 NPS（4-ANPP、mCPP 和 4-甲基苯丙胺），表明肯塔基州 NPS 的流行情况。这是首次在篮球比赛中报告有潜在滥用物质的定量报告。
