Fitzroy Ahren B, Krizman Jennifer, Tierney Adam, Agouridou Manto, Kraus Nina
Department of Communication Sciences and Disorders, Northwestern University Evanston, IL, USA ; Auditory Neuroscience Laboratory, Northwestern University Evanston, IL, USA.
Department of Communication Sciences and Disorders, Northwestern University Evanston, IL, USA ; Auditory Neuroscience Laboratory, Northwestern University Evanston, IL, USA ; Institute for Neuroscience, Northwestern University Evanston, IL, USA ; Department of Neurobiology and Physiology, Northwestern University Evanston, IL, USA ; Department of Otolaryngology, Northwestern University Evanston, IL, USA.
Front Hum Neurosci. 2015 Oct 20;9:530. doi: 10.3389/fnhum.2015.00530. eCollection 2015.
Cross-sectional studies have demonstrated that the cortical auditory evoked potential (CAEP) changes substantially in amplitude and latency from childhood to adulthood, suggesting that these aspects of the CAEP continue to mature through adolescence. However, no study to date has longitudinally followed maturation of these CAEP measures through this developmental period. Additionally, no study has examined the trial-to-trial variability of the CAEP during adolescence. Therefore, we longitudinally tracked changes in the latency, amplitude, and variability of the P1, N1, P2, and N2 components of the CAEP in 68 adolescents from age 14 years to age 17 years. Latency decreased for N1 and N2, and did not change for P1 or P2. Amplitude decreased for P1 and N2, increased for N1, and did not change for P2. Variability decreased with age for all CAEP components. These findings provide longitudinal support for the view that the human auditory system continues to mature through adolescence. Continued auditory system maturation through adolescence suggests that CAEP neural generators remain plastic during this age range and potentially amenable to experience-based enhancement or deprivation.
横断面研究表明，从儿童期到成年期，皮质听觉诱发电位（CAEP）的振幅和潜伏期会发生显著变化，这表明CAEP的这些方面在整个青春期仍在持续成熟。然而，迄今为止，尚无研究纵向跟踪这一发育时期CAEP指标的成熟情况。此外，也没有研究考察青春期CAEP的逐次试验变异性。因此，我们纵向跟踪了68名14岁至17岁青少年CAEP的P1、N1、P2和N2成分的潜伏期、振幅和变异性变化。N1和N2的潜伏期缩短，P1或P2的潜伏期无变化。P1和N2的振幅降低，N1的振幅增加，P2的振幅无变化。所有CAEP成分的变异性均随年龄降低。这些发现为人类听觉系统在整个青春期持续成熟的观点提供了纵向支持。青春期听觉系统的持续成熟表明，CAEP神经发生器在这个年龄范围内仍具有可塑性，并且可能会受到基于经验的增强或剥夺的影响。
