Powell Weston T, Borghese Robyn A, Kalanetra Karen M, Mirmiran Majid, Mills David A, Underwood Mark A
Department of Pediatrics, University of California Davis, Sacramento, CA.
Department of Food Science and Technology, University of California Davis, Davis, CA.
J Pediatr Gastroenterol Nutr. 2016 Jun;62(6):852-857. doi: 10.1097/MPG.0000000000001031.
Infants with gastroschisis often require long periods of gastric suctioning and hospitalization. The impact of these interventions on the intestinal microbiota and attempts to alter the microbial community have not been studied. We sought to determine how the intestinal microbiota is influenced by the current treatment of gastroschisis and whether alteration of the intestinal microbiota with a probiotic microbe will influence length of hospitalization.
We performed a randomized, placebo-controlled pilot study of administration of probiotic Bifidobacterium longum subsp. infantis in 24 infants with gastroschisis. The primary outcome was changes in the fecal microbiota, and the secondary outcome was length of hospital stay.
Administration of the probiotic or placebo was well tolerated, even during the period of gastric suctioning. The overall microbial communities were not significantly different between groups, although analysis of the final specimens by family demonstrated higher Bifidobacteriaceae, lower Clostridiaceae, and trends toward lower Enterobacteriaceae, Enterococcaceae, Staphylococcaceae, and Streptococcaceae in the probiotic group. Clinical outcomes, including length of hospital stay, did not differ between groups.
In this pilot study, there was significant in infants with gastroschisis that was partially attenuated by the administration of B longum subsp. infantis.
腹裂婴儿通常需要长时间的胃肠减压和住院治疗。这些干预措施对肠道微生物群的影响以及改变微生物群落的尝试尚未得到研究。我们试图确定腹裂目前的治疗方法如何影响肠道微生物群，以及用益生菌改变肠道微生物群是否会影响住院时间。
我们对24例腹裂婴儿进行了一项随机、安慰剂对照的益生菌婴儿双歧杆菌亚种给药试验研究。主要结局是粪便微生物群的变化，次要结局是住院时间。
即使在胃肠减压期间，益生菌或安慰剂的给药耐受性也良好。尽管按菌科对最终样本进行分析显示，益生菌组的双歧杆菌科较高、梭菌科较低，且肠杆菌科、肠球菌科、葡萄球菌科和链球菌科有降低趋势，但两组的总体微生物群落无显著差异。两组的临床结局，包括住院时间，没有差异。
在这项试验研究中，腹裂婴儿存在显著变化，给予婴儿双歧杆菌亚种可部分减轻这种变化。
