Liang Kang, Coghlan Campbell J, Bell Stephen G, Doonan Christian, Falcaro Paolo
CSIRO Manufacturing Flagship, Private Bag 10, Clayton South, Victoria 3169, Australia.
Chem Commun (Camb). 2016 Jan 11;52(3):473-6. doi: 10.1039/c5cc07577g. Epub 2015 Nov 9.
Recent studies have demonstrated that metal-organic frameworks can be employed as protective coatings for enzymes. Two efficient strategies have been reported for the synthesis of such composite materials: biomimetic mineralisation and controlled co-precipitation using polyvinylpyrrolidone. We assessed the relative efficacy of each approach by comparing the thermal stability of encapsulated urease. The resulting data shows that over a range of temperatures biomimetic mineralisation offers superior protection than the co-precipitation method.
最近的研究表明，金属有机框架可作为酶的保护涂层。已报道了两种合成此类复合材料的有效策略：仿生矿化和使用聚乙烯吡咯烷酮的可控共沉淀。我们通过比较包封脲酶的热稳定性来评估每种方法的相对效果。所得数据表明，在一定温度范围内，仿生矿化提供的保护比共沉淀法更好。
