Barberi Chiara, Campana Stefania, De Pasquale Claudia, Rabbani Khorasgani Mohammad, Ferlazzo Guido, Bonaccorsi Irene
Laboratory of Immunology and Biotherapy, Dept. Human Pathology, University of Messina, Italy.
Department of Biology, University of Isfahan, Iran.
Immunol Lett. 2015 Dec;168(2):337-42. doi: 10.1016/j.imlet.2015.11.005. Epub 2015 Nov 7.
Different commensal bacteria employed as probiotics have been shown to be endowed with immunomodulatory properties and to actively interact with antigen presenting cells, such as dendritic cells and macrophages. In particular, different strains of probiotic bacteria may induce the secretion of a discrete cytokine profile able to induce divergent T cell polarization. Here, we briefly review current knowledge regarding the effects of different species and strains of probiotic bacteria on T cell polarization. Given that the loss of intestinal homeostasis is frequently associated with an aberrant T cell polarization profile, a comprehensive knowledge of the immunomodulatory potential of these bacteria is crucial for their employment in the management of human immune-mediated pathologies, such as allergies or inflammatory bowel diseases.
不同的共生细菌被用作益生菌，已被证明具有免疫调节特性，并能与抗原呈递细胞（如树突状细胞和巨噬细胞）积极相互作用。特别是，不同菌株的益生菌可能会诱导分泌一系列离散的细胞因子，从而诱导不同的T细胞极化。在此，我们简要回顾一下目前关于不同种类和菌株的益生菌对T细胞极化影响的知识。鉴于肠道内稳态的丧失常常与异常的T细胞极化特征相关，全面了解这些细菌的免疫调节潜力对于将它们用于治疗人类免疫介导的疾病（如过敏或炎症性肠病）至关重要。
