Ghadban Ali, Ahmed Anansa S, Ping Yuan, Ramos Ricardo, Arfin Najmul, Cantaert Bram, Ramanujan Raju V, Miserez Ali
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Chem Commun (Camb). 2016 Jan 14;52(4):697-700. doi: 10.1039/c5cc08617e.
We have developed pH- and magnetic-responsive hydrogels that are stabilized by both covalent bonding and catechol/Fe(3+) ligands. The viscoelastic properties of the gels are regulated by the complexation valence and can be used to tune drug release profiles. The stable incorporation of magnetic nanoparticles further expands control over the mechanical response and drug release, in addition to providing magnetic stimuli-responsivity to the gels.
我们已经开发出了通过共价键和儿茶酚/铁（III）配体稳定的pH和磁响应水凝胶。凝胶的粘弹性特性由络合价调节，可用于调整药物释放曲线。磁性纳米颗粒的稳定掺入除了为凝胶提供磁刺激响应性之外，还进一步扩展了对机械响应和药物释放的控制。
