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生物相容的导电水凝胶:在生物医学领域的应用。

Biocompatible Conductive Hydrogels: Applications in the Field of Biomedicine.

机构信息

College of Intelligence Science and Technology, National University of Defense Technology, Changsha 410073, China.

出版信息

Int J Mol Sci. 2022 Apr 21;23(9):4578. doi: 10.3390/ijms23094578.

Abstract

The impact of COVID-19 has rendered medical technology an important factor to maintain social stability and economic increase, where biomedicine has experienced rapid development and played a crucial part in fighting off the pandemic. Conductive hydrogels (CHs) are three-dimensional (3D) structured gels with excellent electrical conductivity and biocompatibility, which are very suitable for biomedical applications. CHs can mimic innate tissue's physical, chemical, and biological properties, which allows them to provide environmental conditions and structural stability for cell growth and serve as efficient delivery substrates for bioactive molecules. The customizability of CHs also allows additional functionality to be designed for different requirements in biomedical applications. This review introduces the basic functional characteristics and materials for preparing CHs and elaborates on their synthetic techniques. The development and applications of CHs in the field of biomedicine are highlighted, including regenerative medicine, artificial organs, biosensors, drug delivery systems, and some other application scenarios. Finally, this review discusses the future applications of CHs in the field of biomedicine. In summary, the current design and development of CHs extend their prospects for functioning as an intelligent and complex system in diverse biomedical applications.

摘要

新冠疫情的爆发使医疗技术成为维护社会稳定和促进经济增长的重要因素,其中,生物医药得到了迅猛发展,并在抗击疫情中发挥了关键作用。导电水凝胶(CHs)是一种具有优异导电性和生物相容性的三维(3D)结构凝胶,非常适合生物医学应用。CHs 可以模拟天然组织的物理、化学和生物学特性,为细胞生长提供环境条件和结构稳定性,并作为生物活性分子的有效输送载体。CHs 的可定制性还允许为生物医学应用中的不同需求设计额外的功能。本综述介绍了 CHs 的基本功能特性和材料制备,并详细阐述了其合成技术。强调了 CHs 在再生医学、人工器官、生物传感器、药物输送系统以及其他一些应用场景等生物医学领域的发展和应用。最后,本文讨论了 CHs 在生物医学领域的未来应用。总之,目前 CHs 的设计和开发扩展了它们在各种生物医学应用中作为智能复杂系统的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f6/9104506/40d3aa00c32d/ijms-23-04578-g001.jpg

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