a State Key Laboratory of Food Science and Technology, Nanchang University Nanchang , CN, Nanchang , China.
Crit Rev Food Sci Nutr. 2017 Jul 24;57(11):2432-2454. doi: 10.1080/10408398.2015.1077194.
Phyto-estrogens are plant-derived compounds that can exert various estrogenic and anti-estrogenic effects, and are usually used as a natural alternative to estrogen replacement due to their health benefits, including a lowered risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms. Phyto-estrogens are also considered as endocrine disruptors due to their structure similar to human female hormone 17-β oestradiol. However, the issue of whether phyto-estrogens are beneficial or harmful to human health remains unknown, as this may depend on the dose, form, level and duration of administration of phyto-estrogens, and influence by genetics, metabolism, gut physiology, age, diet, and the health status of individuals. Clarification on this issue is necessary for the sake of their two-side effects on human health and rapidly increasing global consumption of phyto-estrogens. This review mainly includes the metabolism of phyto-estrogens and weighs the evidence for and against the purported health benefits and adverse effects of phyto-estrogens.
植物雌激素是植物来源的化合物，具有多种雌激素和抗雌激素作用，通常因其健康益处而被用作雌激素替代物，包括降低骨质疏松症、心脏病、乳腺癌和更年期症状的风险。由于其结构类似于人类女性激素 17-β 雌二醇，植物雌激素也被认为是内分泌干扰物。然而，植物雌激素对人类健康是有益还是有害的问题仍不清楚，因为这可能取决于植物雌激素的剂量、形式、水平和给药时间，以及遗传、代谢、肠道生理学、年龄、饮食和个体健康状况的影响。为了了解植物雌激素对人类健康的双重影响以及其在全球范围内的消费迅速增加，有必要对此问题进行澄清。本综述主要包括植物雌激素的代谢，并权衡了植物雌激素据称的健康益处和不良反应的证据。
