诺如病毒疫苗和潜在的抗诺如病毒药物：最新进展与未来展望。
Norovirus vaccines and potential antinorovirus drugs: recent advances and future perspectives.
作者信息
Kocher Jacob, Yuan Lijuan
机构信息
Department of Biomedical Sciences & Pathobiology, Center for Molecular Medicine & Infectious Diseases, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute & State University, Blacksburg, VA 24061-0913, USA.
出版信息
Future Virol. 2015;10(7):899-913. doi: 10.2217/fvl.15.57.
Abstract
Human noroviruses (HuNoVs) are a leading cause of acute, nonbacterial gastroenteritis worldwide. The lack of a cell culture system and smaller animal model has delayed the development and commercial availability of vaccines and antiviral drugs. Current vaccines rely on recombinant capsid proteins, such as P particles and virus-like particles (VLPs), which have been promising in clinical trials. Anti-HuNoV drug development is another area of extensive research, including currently available antiviral drugs for other viral pathogens. This review will provide an overview of recent advances in vaccine and antiviral development. The implication of recent advances in HuNoV cell culture for improving vaccine and antiviral development is also discussed.
摘要
人诺如病毒（HuNoVs）是全球急性非细菌性胃肠炎的主要病因。缺乏细胞培养系统和小型动物模型延缓了疫苗和抗病毒药物的研发及商业化应用。目前的疫苗依赖重组衣壳蛋白，如P颗粒和病毒样颗粒（VLPs），这些在临床试验中已显示出前景。抗HuNoV药物研发是另一个广泛研究的领域，包括目前用于其他病毒病原体的抗病毒药物。本综述将概述疫苗和抗病毒药物研发的最新进展。还将讨论HuNoV细胞培养的最新进展对改进疫苗和抗病毒药物研发的意义。
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