Milner G R, Testa N G, Geary C G, Dexter T M, Muldal S, MacIver J E, Lajtha L G
Br J Haematol. 1977 Feb;35(2):251-61. doi: 10.1111/j.1365-2141.1977.tb00582.x.
As an adjunct to conventional haematological and cytogenetic data, 22 cases of refractory cytopenia, and five with chronic myelomonocytic leukaemia, (CMML) were studied by bone marrow culture. Cultures from II such patients without an excess of marrow myeloblasts usually showed low, or undetectable, numbers of cells capable of giving rise to colonies of granulocytes and/or macrophages (CFUc) but near-normal numbers of cluster-forming cells and cells capable of forming erythroid colonies (CFUE). Those with similar blood pictures, but in whom the marrow contained a slight excess of myeloblasts (II cases), showed a more profound defect in growth patterns: low or undetectable numbers of CFUC, clusters and CFUE, results similar to those found in acute myeloblastic leukaemia, into which three of this group evolved. The patients with CMML gave comparatively normal CFUC, cluster and CFUE growth patterns.
作为传统血液学和细胞遗传学数据的补充，我们通过骨髓培养对22例难治性血细胞减少症患者以及5例慢性粒单核细胞白血病（CMML）患者进行了研究。11例骨髓原始粒细胞不过多的此类患者的培养物通常显示，能够产生粒细胞和/或巨噬细胞集落（CFUc）的细胞数量较低或检测不到，但集落形成细胞和能够形成红系集落的细胞（CFUE）数量接近正常。那些具有相似血象，但骨髓中原始粒细胞略有增多的患者（11例），其生长模式存在更严重的缺陷：CFUC、集落和CFUE数量较低或检测不到，结果与急性髓细胞白血病相似，该组中有3例进展为急性髓细胞白血病。CMML患者的CFUC、集落和CFUE生长模式相对正常。
