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睡眠的神经保护作用

The Neuroprotective Aspects of Sleep.

作者信息

Eugene Andy R, Masiak Jolanta

机构信息

Division of Clinical Pharmacology/Anesthesia Research, Department of Molecular Pharmacology and Experimental Therapeutics, Gonda 19, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.

Neurophysiology Unit, Department of Psychiatry, Medical University of Lublin, ul. Gluska 1, Lublin 20-439, Poland.

出版信息

MEDtube Sci. 2015 Mar;3(1):35-40.

Abstract

Sleep is an important component of human life, yet many people do not understand the relationship between the brain and the process of sleeping. Sleep has been proven to improve memory recall, regulate metabolism, and reduce mental fatigue. A minimum of 7 hours of daily sleep seems to be necessary for proper cognitive and behavioral function. The emotional and mental handicaps associated with chronic sleep loss as well as the highly hazardous situations which can be contributed to the lack of sleep is a serious concern that people need to be aware of. When one sleeps, the brain reorganizes and recharges itself, and removes toxic waste byproducts which have accumulated throughout the day. This evidence demonstrates that sleeping can clear the brain and help maintain its normal functioning. Multiple studies have been done to determine the effects of total sleep deprivation; more recently some have been conducted to show the effects of sleep restriction, which is a much more common occurrence, have the same effects as total sleep deprivation. Each phase of the sleep cycle restores and rejuvenates the brain for optimal function. When sleep is deprived, the active process of the glymphatic system does not have time to perform that function, so toxins can build up, and the effects will become apparent in cognitive abilities, behavior, and judgment. As a background for this paper we have reviewed literature and research of sleep phases, effects of sleep deprivation, and the glymphatic system of the brain and its restorative effect during the sleep cycle.

摘要

睡眠是人类生活的重要组成部分,但许多人并不理解大脑与睡眠过程之间的关系。事实证明,睡眠有助于提高记忆能力、调节新陈代谢并减轻精神疲劳。每天至少7小时的睡眠似乎是维持正常认知和行为功能所必需的。与长期睡眠不足相关的情绪和心理障碍,以及因睡眠不足可能导致的高度危险情况,是人们需要意识到的一个严重问题。人睡觉时,大脑会进行自我重组和充电,并清除一天中积累的有毒废物副产品。这一证据表明,睡眠可以清理大脑并帮助维持其正常功能。已经进行了多项研究来确定完全剥夺睡眠的影响;最近,一些研究表明,睡眠限制(这是一种更为常见的情况)与完全剥夺睡眠具有相同的影响。睡眠周期的每个阶段都会恢复大脑活力,使其达到最佳功能状态。当睡眠被剥夺时,类淋巴系统的活跃过程就没有时间执行该功能,因此毒素会积聚,其影响将在认知能力、行为和判断力方面显现出来。作为本文的背景,我们回顾了有关睡眠阶段、睡眠剥夺的影响以及大脑类淋巴系统及其在睡眠周期中的恢复作用的文献和研究。

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