Si Jiyeon, Lee Sunghee, Park Jin Mo, Sung Joohon, Ko GwangPyo
Department of Environmental Health, School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
BMC Genomics. 2015 Nov 23;16:992. doi: 10.1186/s12864-015-2131-y.
The skin is the outermost layer of the human body and one of the key sites for host-microbe interactions. Both environmental and host genetic factors influence microbial communities in distinct anatomical niches, but little is known about their interplay in shaping the skin microbiome. Here, we investigate the heritable components of the skin microbiome and their association with host genetic factors.
Based on our analysis of the microbiota from 45 individuals including monozygotic and dizygotic twins aged 26-55 years and their mothers, we found that skin microbial diversity was significantly influenced by age and skin pigmentation. Heritability analysis revealed genetic and shared environmental impacts on the skin microbiome. Furthermore, we observed a strong association between the abundance of Corynebacterium jeikeium and single nucleotide polymorphisms (SNPs) in the host FLG gene related to epidermal barrier function.
This study reveals an intimate association of the human skin microbiome and host genes, and increases our understanding of the role of human genetic factors in establishing a microbial ecosystem on the body surface.
皮肤是人体的最外层，也是宿主与微生物相互作用的关键部位之一。环境和宿主遗传因素都会影响不同解剖部位的微生物群落，但它们在塑造皮肤微生物群方面的相互作用却鲜为人知。在此，我们研究皮肤微生物群的可遗传成分及其与宿主遗传因素的关联。
基于对45名个体（包括年龄在26至55岁之间的同卵和异卵双胞胎及其母亲）的微生物群分析，我们发现皮肤微生物多样性受年龄和皮肤色素沉着的显著影响。遗传力分析揭示了遗传和共同环境对皮肤微生物群的影响。此外，我们观察到杰氏棒状杆菌的丰度与宿主FLG基因中与表皮屏障功能相关的单核苷酸多态性（SNP）之间存在强烈关联。
本研究揭示了人类皮肤微生物群与宿主基因之间的密切关联，并增进了我们对人类遗传因素在体表建立微生物生态系统中所起作用的理解。
