合成基因网络的应用。
Applications of synthetic gene networks.
作者信息
Wu Fuqing, Wang Xiao
出版信息
Sci Prog. 2015;98(Pt 3):244-52. doi: 10.3184/003685015X14368807556441.
Abstract
Synthetic gene networks have evolved from simple proof-of-concept circuits to complex therapy-oriented networks over the past 15 years. This advancement has greatly facilitated the expansion of the emerging field of synthetic biology. In this review, we highlight the main applications ofsynthetic gene networks in understanding biological design principles, developing biosensors for diagnosis, producing industrial and biomedical compounds, and treating human diseases. Finally, we outline current challenges and future prospects of synthetic gene networks for advancing practical applications.
摘要
在过去15年里，合成基因网络已从简单的概念验证电路发展为复杂的面向治疗的网络。这一进展极大地推动了合成生物学这一新兴领域的扩展。在本综述中，我们重点介绍了合成基因网络在理解生物学设计原理、开发用于诊断的生物传感器、生产工业和生物医学化合物以及治疗人类疾病方面的主要应用。最后，我们概述了合成基因网络在推进实际应用方面当前面临的挑战和未来前景。
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2
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Cell. 2014 Nov 6;159(4):940-54. doi: 10.1016/j.cell.2014.10.004. Epub 2014 Oct 23.
3
Toehold switches: de-novo-designed regulators of gene expression.适体开关：基因表达的全新设计调控器。
Cell. 2014 Nov 6;159(4):925-39. doi: 10.1016/j.cell.2014.10.002. Epub 2014 Oct 23.
4
Gene networks of fully connected triads with complete auto-activation enable multistability and stepwise stochastic transitions.具有完全自激活的全连接三元组基因网络可实现多稳态和逐步随机转变。
PLoS One. 2014 Jul 24;9(7):e102873. doi: 10.1371/journal.pone.0102873. eCollection 2014.
5
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6
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8
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