Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany.
Curr Opin Biotechnol. 2012 Oct;23(5):703-11. doi: 10.1016/j.copbio.2012.01.003. Epub 2012 Feb 1.
The field of synthetic biology is rapidly expanding and has over the past years evolved from the development of simple gene networks to complex treatment-oriented circuits. The reprogramming of cell fate with open-loop or closed-loop synthetic control circuits along with biologically implemented logical functions have fostered applications spanning over a wide range of disciplines, including artificial insemination, personalized medicine and the treatment of cancer and metabolic disorders. In this review we describe several applications of interactive gene networks, a synthetic biology-based approach for future gene therapy, as well as the utilization of synthetic gene circuits as blueprints for the design of stimuli-responsive biohybrid materials. The recent progress in synthetic biology, including the rewiring of biosensing devices with the body's endogenous network as well as novel therapeutic approaches originating from interdisciplinary work, generates numerous opportunities for future biomedical applications.
合成生物学领域正在迅速扩张，近年来已从简单基因网络的开发发展到复杂的面向治疗的电路。通过开环或闭环合成控制电路以及生物实现的逻辑功能对细胞命运进行重新编程，促进了跨越多个学科的应用，包括人工授精、个性化医疗以及癌症和代谢紊乱的治疗。在这篇综述中，我们描述了交互式基因网络的几种应用，这是一种基于合成生物学的未来基因治疗方法，以及将合成基因电路用作设计对刺激响应的生物混合材料的蓝图。合成生物学的最新进展，包括用身体内源性网络对生物传感设备进行重新布线，以及源自跨学科工作的新型治疗方法，为未来的生物医学应用创造了众多机会。
