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吸烟与慢性胰腺炎计算机断层扫描结果进展之间的关联。

Association between Smoking and the Progression of Computed Tomography Findings in Chronic Pancreatitis.

作者信息

Lee Jeong Woo, Kim Ho Gak, Lee Dong Wook, Han Jimin, Kwon Hyuk Yong, Seo Chang Jin, Oh Ji Hye, Lee Joo Hyoung, Jung Jin Tae, Kwon Joong Goo, Kim Eun Young

机构信息

Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.

出版信息

Gut Liver. 2016 May 23;10(3):464-9. doi: 10.5009/gnl14289.

Abstract

BACKGROUND/AIMS: Smoking and alcohol intake are two wellknown risk factors for chronic pancreatitis. However, there are few studies examining the association between smoking and changes in computed tomography (CT) findings in chronic pancreatitis. The authors evaluated associations between smoking, drinking and the progression of calcification on CT in chronic pancreatitis.

METHODS

In this retrospective study, 59 patients with chronic pancreatitis who had undergone initial and follow-up CT between January 2002 and September 2010 were included. Progression of calcification among CT findings was compared according to the amount of alcohol intake and smoking.

RESULTS

The median duration of followup was 51.6 months (range, 17.1 to 112.7 months). At initial CT findings, there was pancreatic calcification in 35 patients (59.3%). In the follow-up CT, progression of calcification was observed in 37 patients (62.7%). Progression of calcification was more common in smokers according to the multivariate analysis (odds ratio [OR], 9.987; p=0.006). The amount of smoking was a significant predictor for progression of calcification in the multivariate analysis (OR, 6.051 in less than 1 pack per day smokers; OR, 36.562 in more than 1 pack per day smokers; p=0.008).

CONCLUSIONS

Continued smoking accelerates pancreatic calcification, and the amount of smoking is associated with the progression of calcification in chronic pancreatitis.

摘要

背景/目的:吸烟和饮酒是慢性胰腺炎两个众所周知的危险因素。然而,很少有研究探讨吸烟与慢性胰腺炎计算机断层扫描(CT)结果变化之间的关联。作者评估了吸烟、饮酒与慢性胰腺炎CT上钙化进展之间的关联。

方法

在这项回顾性研究中,纳入了2002年1月至2010年9月期间接受过初次和随访CT检查的59例慢性胰腺炎患者。根据饮酒量和吸烟情况比较CT检查结果中钙化的进展情况。

结果

随访的中位时间为51.6个月(范围17.1至112.7个月)。初次CT检查时,35例患者(59.3%)有胰腺钙化。在随访CT中,37例患者(62.7%)观察到钙化进展。多因素分析显示,吸烟者钙化进展更常见(优势比[OR],9.987;p = 0.006)。在多因素分析中,吸烟量是钙化进展的重要预测因素(每天吸烟少于1包者的OR为6.051;每天吸烟超过1包者的OR为36.562;p = 0.008)。

结论

持续吸烟会加速胰腺钙化,且吸烟量与慢性胰腺炎钙化的进展有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc94/4849701/1d7b1033182b/gnl-10-464f1.jpg

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