Shook R P, Hand G A, Paluch A E, Wang X, Moran R, Hébert J R, Jakicic J M, Blair S N
Department of Kinesiology, Iowa State University, Ames, IA, USA.
School of Public Health, University of West Virginia, Morgantown, WV, USA.
Eur J Clin Nutr. 2016 Oct;70(10):1197-1202. doi: 10.1038/ejcn.2015.198. Epub 2015 Nov 25.
BACKGROUND/OBJECTIVES: Metabolic disturbances, such as reduced rates of fat oxidation (high respiratory quotient (RQ)) or low energy expenditure (low resting metabolic rate (RMR)), may contribute to obesity. The objective was to determine the association between a high RQ or a low RMR and changes in body weight and body composition over 1 year.
SUBJECTS/METHODS: We measured RQ and RMR in 341 adults using indirect calorimetry, along with body weight/body composition using dual-energy X-ray absorptiometery, energy expenditure using an arm-based activity monitor and energy intake using dietary recalls. Participants were classified into low, moderate or high RQ and RMR (adjusted for age, sex, race and body composition) groups according to tertiles by sex. Follow-up measurements were completed every 3 months.
Individuals with a high RQ had larger gains in body weight and fat mass compared with individuals with a low/moderate RQ at month 3, and increases in fat mass were more than double among individuals with a high RQ at 12 months (1.3±3.0 vs 0.6±3.7 kg, P=0.03). Individuals with a low RMR did not gain more body weight nor fat mass compared with individuals with a moderate/high RMR.
The primary finding is a high RQ is predictive of gains in body weight and fat mass over a 12-month period among young adults, with changes occurring as soon as 3 months. In addition, a low RMR was not associated with gains in body weight or fat mass over the same period.
背景/目的：代谢紊乱，如脂肪氧化率降低（高呼吸商（RQ））或低能量消耗（低静息代谢率（RMR）），可能导致肥胖。目的是确定高RQ或低RMR与1年内体重和身体成分变化之间的关联。
受试者/方法：我们使用间接测热法测量了341名成年人的RQ和RMR，同时使用双能X线吸收法测量了体重/身体成分，使用基于手臂的活动监测器测量了能量消耗，并通过饮食回忆法测量了能量摄入。根据性别三分位数，将参与者分为低、中、高RQ和RMR（根据年龄、性别、种族和身体成分进行调整）组。每3个月完成一次随访测量。
与低/中度RQ的个体相比，高RQ的个体在第3个月时体重和脂肪量增加更大，在12个月时，高RQ个体的脂肪量增加超过两倍（1.3±3.0 vs 0.6±3.7 kg，P=0.03）。与中度/高度RMR的个体相比，低RMR的个体体重和脂肪量增加并不更多。
主要发现是，高RQ可预测年轻成年人在12个月内体重和脂肪量的增加，且在3个月时就会出现变化。此外，低RMR与同期体重或脂肪量的增加无关。
