Jaypee University of Information Technology, Waknaghat, Solan 173234, Himachal Pradesh, India.
Jaypee University of Information Technology, Waknaghat, Solan 173234, Himachal Pradesh, India.
Eur Neuropsychopharmacol. 2016 Jan;26(1):78-91. doi: 10.1016/j.euroneuro.2015.11.002. Epub 2015 Nov 14.
Social behavior plays a pivotal role in the mental well-being of an individual. Continuous efforts in the past have led to advancements in the area of how the brain regulates emotion and cognition, while the understanding of human social behavior still remains eluded. A major breakthrough in understanding the etiology of neurological disorders is the recent insight on the role of the gut microbiota (GM). Human GM also referred to as the "forgotten organ" is home to 10(13-14) microorganisms, which is 10 times the number of cells present in the human body. In addition, the gut microbiome (total genome of GM) is 150 times greater as compared to the human genome. An emerging concept gaining worldwide focus and acceptance is that, this much big genome can potentially control human behavior and other biological functions. Herein we hypothesize on the basis of GM's ability to modify brain and behavior and that it can directly or indirectly control social behavior. This review focuses on the association of GM with various domains of social behavior like stress, cognition and anxiety.
社会行为在个体的心理健康中起着关键作用。过去的持续努力推动了大脑如何调节情绪和认知领域的发展，而人类社会行为的理解仍然难以捉摸。理解神经紊乱病因学的一个重大突破是最近对肠道微生物群（GM）作用的认识。人类 GM 也被称为“被遗忘的器官”，是 10(13-14)种微生物的家园，是人体内存在的细胞数量的 10 倍。此外，肠道微生物组（GM 的总基因组）比人类基因组大 150 倍。一个正在获得全球关注和认可的新兴概念是，这个庞大的基因组可能能够控制人类的行为和其他生物功能。基于 GM 修饰大脑和行为的能力，我们在此假设它可以直接或间接地控制社会行为。本综述重点介绍了 GM 与压力、认知和焦虑等各种社会行为领域的关联。
