Aytac Zeynep, Kusku Semran Ipek, Durgun Engin, Uyar Tamer
Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey; UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.
UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey; Department of Engineering Physics, Istanbul Medeniyet University, 34700 Göztepe-Istanbul, Turkey.
Food Chem. 2016 Apr 15;197(Pt A):864-71. doi: 10.1016/j.foodchem.2015.11.051. Epub 2015 Nov 12.
Electrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating β-cyclodextrin inclusion complex (β-CD-IC) of quercetin (QU) was performed. Here, β-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/β-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/β-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/β-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/β-CD-IC-NF was much slower but greater in total than from PAA/QU/β-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/β-CD-IC-NF.
进行了将槲皮素（QU）的β-环糊精包合物（β-CD-IC）掺入聚丙烯酸（PAA）纳米纤维（NF）的静电纺丝。在此，β-CD不仅用作PAA纳米纤维的交联剂，还用作包合QU的主体分子。相溶解度试验表明，由于包合络合作用，QU的溶解度增强；此外，确定QU/β-CD-IC的化学计量比为1:1。计算模型研究证实，形成1:1和1:2的络合物是理想的；选择1:1的络合物形成以具有更高的QU负载量。扫描电子显微镜图像显示PAA/QU/β-CD-IC-NF无珠且均匀。X射线衍射表明PAA/QU/β-CD-IC-NF本质上是无定形的，没有QU的结晶峰。比较结果表明，QU从PAA/QU/β-CD-IC-NF中的释放曲线要慢得多，但总量比从PAA/QU/β-CD-IC薄膜中的释放量大。此外，在PAA/QU/β-CD-IC-NF中实现了QU的高抗氧化活性和光稳定性。
