Al-Daghri Nasser M, Al-Ajlan Abdulrahman Sm, Alfawaz Hanan, Yakout Sobhy M, Aljohani Naji, Kumar Sudhesh, Alokail Majed S
Department of Biochemistry, Prince Mutaib Chair for Biomarkers of Osteoporosis, College of Science, King Saud University Riyadh 11451, Saudi Arabia ; Department of Biochemistry, Biomarkers Research Program, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
College of Applied Medical Sciences, Department of Clinical Laboratory Sciences, King Saud University Riyadh, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
Int J Clin Exp Pathol. 2015 Sep 1;8(9):11587-93. eCollection 2015.
Approximately 5-10% of subjects with pre-diabetes eventually progress to diabetes every year. While inflammation is thought to be involved in the development of obesity-related type 2 diabetes mellitus (T2DM), the relation between inflammation and pre-diabetes remains largely unexplored. In this study we examined a comprehensive panel of 10 serum biomarkers involved in overweight and obese subjects with pre-diabetes. A total of 98 subjects (23 males, 75 females) were advised to reduce total intake of fat, increase fiber intake and physical activity. Serum cytokines, MCP and other hormones were assessed by multiplex cytokine profiling. Results show that CRP, IL-6, leptin, IL-10, MCP, resistin, serpin, and TNF-α were significantly lower after 12-months than baseline. Serum concentrations of other adipocytokines, including adipsin and leptin were modestly lower in the 12-month follow-up than baseline, but failed to reach statistical significance. Changes in HbA1c was found to be positively correlated with adipsin, CRP, IL-6, IL-10, resistin, serpin, and TNF-α. The results suggest that promotion of lifestyle changes for one year among overweight and obese subjects modestly changes several circulating inflammatory biomarkers which maybe favorable in reducing risk for T2DM progression.
每年约有5%-10%的糖尿病前期患者最终会发展为糖尿病。虽然炎症被认为与肥胖相关的2型糖尿病（T2DM）的发生有关，但炎症与糖尿病前期之间的关系在很大程度上仍未得到探索。在本研究中，我们检测了一组包含10种血清生物标志物的综合指标，这些指标涉及超重和肥胖的糖尿病前期患者。总共98名受试者（23名男性，75名女性）被建议减少脂肪总摄入量、增加纤维摄入量并加强体育锻炼。通过多重细胞因子分析评估血清细胞因子、单核细胞趋化蛋白（MCP）和其他激素。结果显示，12个月后，C反应蛋白（CRP）、白细胞介素-6（IL-6）、瘦素、白细胞介素-10（IL-10）、MCP、抵抗素、丝氨酸蛋白酶抑制剂和肿瘤坏死因子-α（TNF-α）均显著低于基线水平。在12个月的随访中，包括脂肪酶和瘦素在内的其他脂肪细胞因子的血清浓度略低于基线水平，但未达到统计学显著性。糖化血红蛋白（HbA1c）的变化与脂肪酶、CRP、IL-6、IL-10、抵抗素、丝氨酸蛋白酶抑制剂和TNF-α呈正相关。结果表明，超重和肥胖受试者进行为期一年的生活方式改变，会适度改变几种循环炎症生物标志物，这可能有利于降低T2DM进展的风险。
