Bandarian Vahe, Drennan Catherine L
Department of Chemistry, University of Utah, Salt Lake City, UT 84112, United States.
Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Chemistry, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Curr Opin Struct Biol. 2015 Dec;35:116-24. doi: 10.1016/j.sbi.2015.11.005. Epub 2015 Nov 28.
Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
含吡咯并嘧啶的天然产物在自然界中广泛分布。所有吡咯并嘧啶共有的7-脱氮嘌呤部分的生物合成需要多个步骤，其中之一是由CDG合酶催化的复杂自由基介导的环收缩反应。在此，我们综述脱氮嘌呤的生物合成途径，重点关注对CDG合酶的生化和结构见解。
