头孢曲松-奈替米星联合用药单日剂量治疗实验性大肠杆菌心内膜炎
Ceftriaxone-netilmicin combination in single-daily-dose treatment of experimental Escherichia coli endocarditis.
作者信息
Fantin B, Pangon B, Potel G, Vallois J M, Caron F, Bure A, Carbon C
机构信息
Institut National de la Santé et de la Recherche Médicale U.13, Hôpital Claude Bernard, Université Paris VII, France.
出版信息
Antimicrob Agents Chemother. 1989 May;33(5):767-70. doi: 10.1128/AAC.33.5.767.
Abstract
We evaluated the activities of ceftriaxone (15 mg/kg), netilmicin (6 mg/kg), and their combination given intramuscularly once daily for 4 days for the treatment of experimental Escherichia coli endocarditis in rabbits. In vitro, a greater rate of killing and an increased trough serum bactericidal titer (P less than 0.01) were achieved with the combination. In vivo, the combination had a greater bactericidal effect (P less than 0.01) and resulted in a greater number of sterile vegetations (P less than 0.05) than single-drug therapy. Thus, in vivo, an increased effect can be obtained despite a single daily dose of a long-acting cephalosporin and an aminoglycoside.
摘要
我们评估了头孢曲松（15毫克/千克）、奈替米星（6毫克/千克）及其联合用药（每日一次肌肉注射，共4天）治疗兔实验性大肠杆菌心内膜炎的效果。在体外，联合用药实现了更高的杀菌率和更高的谷浓度血清杀菌效价（P<0.01）。在体内，联合用药比单一药物治疗具有更强的杀菌效果（P<0.01），并导致无菌赘生物数量更多（P<0.05）。因此，在体内，尽管每日仅使用一剂长效头孢菌素和一种氨基糖苷类药物，仍可获得增强的疗效。
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