Faculty of Rehabilitation and Kinesiology, Department of Health Promotion and Posturology, Gdansk University of Physical Education and Sport, K. Gorskiego 1, 80-336 Gdansk, Poland.
Faculty of Rehabilitation and Kinesiology, Department of Physiotherapy, Gdansk University of Physical Education and Sport, K. Gorskiego 1, 80-336 Gdansk, Poland.
Int J Environ Res Public Health. 2018 Sep 20;15(10):2064. doi: 10.3390/ijerph15102064.
The aim of the study was to verify if coupling 12 weeks of vitamin D supplementation and Nordic walking training favoured lowering the homocysteine (Hcy) level. Ninety-four elderly women were divided into three groups: Nordic walking (NW), supplemented (SG) and control (CG). The NW and SG groups received a weekly dose of 28,000 IU of vitamin D3. A blood analysis was performed at baseline, 1h after the first training session and at the end of the experiment. The amino acid profile (methionine and cysteine) and homocysteine concentration were determined. Additionally, the concentration of myokine was assessed. The first session of NW training reduced serum homocysteine, particularly among women with baseline homocysteine above 10 µmol·L: 12.37 ± 2.75 vs. 10.95 ± 3.94 µmol·L ( = 0.05). These changes were accompanied by shifts in the cysteine ( = 0.09) and methionine ( = 0.01) concentration, regardless of the Hcy concentration. Twelve weeks of training significantly decreased the homocysteine (9.91 ± 2.78, vs. 8.90 ± 3.14 µmol·L, = 0.05) and ferritin (94.23 ± 62.49 vs. 73.15 ± 47.04 ng·mL, = 0.05) concentrations in whole NW group. Also, in the NW group, ferritin correlated with the glucose level (r = 0.51, = 0.00). No changes in the myokine levels were observed after the intervention. Only the brain-derived neurotrophic factor dropped in the NW (42.74 ± 19.92 vs. 31.93 ± 15.91 ng·mL, = 0.01) and SG (37.75 ± 8.08 vs. 16.94 ± 12.78 ng·mL, = 0.00) groups. This study presents a parallel decrease of homocysteine and ferritin in response to regular training supported by vitamin D supplementation.
本研究旨在验证补充 12 周维生素 D 并结合北欧式健走训练是否有助于降低同型半胱氨酸（Hcy）水平。94 名老年女性被分为三组：北欧式健走（NW）组、补充组（SG）和对照组（CG）。NW 和 SG 组每周接受 28000IU 的维生素 D3。在基线、第一次训练后 1 小时和实验结束时进行血液分析。测定氨基酸谱（蛋氨酸和半胱氨酸）和同型半胱氨酸浓度。此外，还评估了肌因子的浓度。第一次北欧式健走训练降低了血清同型半胱氨酸，尤其是基线同型半胱氨酸高于 10µmol·L 的女性：12.37±2.75 与 10.95±3.94µmol·L（ = 0.05）。这些变化伴随着半胱氨酸（ = 0.09）和蛋氨酸（ = 0.01）浓度的变化，而与 Hcy 浓度无关。12 周的训练显著降低了同型半胱氨酸（9.91±2.78 与 8.90±3.14µmol·L， = 0.05）和铁蛋白（94.23±62.49 与 73.15±47.04ng·mL， = 0.05）在整个 NW 组中的浓度。此外，在 NW 组中，铁蛋白与血糖水平呈正相关（r = 0.51， = 0.00）。干预后肌因子水平没有变化。只有脑源性神经营养因子在 NW（42.74±19.92 与 31.93±15.91ng·mL， = 0.01）和 SG（37.75±8.08 与 16.94±12.78ng·mL， = 0.00）组中下降。本研究表明，在维生素 D 补充支持下进行规律训练可使同型半胱氨酸和铁蛋白同时降低。
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