Wang Wei-Guang, Li Ao, Yan Bing-Chao, Niu Shu-Bin, Tang Jian-Wei, Li Xiao-Nian, Du Xue, Challis Gregory L, Che Yongsheng, Sun Han-Dong, Pu Jian-Xin
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
College of Pharmacy and Bioengineering, Chongqing University of Technology , Chongqing 400054, People's Republic of China.
J Nat Prod. 2016 Jan 22;79(1):149-55. doi: 10.1021/acs.jnatprod.5b00814. Epub 2015 Dec 18.
Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-β (TGF-β)/Smad signaling.
青霉呋喃酮A（1）是一种新型呋喃羧酸，及其推测的生物合成前体格雷加汀A（2），是在高效液相色谱-质谱引导下，从内生毛萼香茶菜疏松变种茎中的青霉属真菌Penicillium sp. sh18的培养物中分离得到的。首次将X射线晶体学应用于呋喃羧酸的结构测定，从而明确确定了1的结构。青霉呋喃酮A通过对转化生长因子-β（TGF-β）/Smad信号通路的负调控，在活化的肝星状细胞中显示出显著的抗纤维化作用。
