有症状的周围神经卡压性神经病患者的单磷酸尿苷、叶酸和维生素B12
Uridine monophosphate, folic acid and vitamin B12 in patients with symptomatic peripheral entrapment neuropathies.
作者信息
Negrão Luis, Nunes Paula
机构信息
Neuromuscular Diseases Unit, Neurology Service, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
UCSP Convenção, Odivelas, Lisboa, Portugal.
出版信息
Pain Manag. 2016;6(1):25-9. doi: 10.2217/pmt.15.60. Epub 2015 Dec 17.
BACKGROUND
Carpal tunnel syndrome is the most common type of peripheral entrapment neuropathy.
PATIENTS & METHODS: We performed an exploratory, open-label, multicenter, observational study of 48 patients with peripheral entrapment neuropathy. Patients received a daily capsule of uridine monophosphate, folic acid + vitamin B12 for 2 months and were evaluated using the Pain DETECT questionnaire.
RESULTS
The global score for pain decreased from 17.3 ± 5.9 at baseline to 10.3 ± 6.1 at the final evaluation (p < 0.001). Concomitant analgesic and anti-inflammatory treatment was stopped or the dose reduced in 77.4% of patients.
CONCLUSION
Uridine monophosphate + folic acid + vitamin B12 reduced total pain score, intensity and characterization of pain and associated symptoms. These results should be tested in a well-designed, adequately powered randomized controlled trial.
背景
腕管综合征是最常见的周围神经卡压性神经病类型。
患者与方法
我们对48例周围神经卡压性神经病患者进行了一项探索性、开放标签、多中心观察性研究。患者每日服用一粒单磷酸尿苷、叶酸 + 维生素B12胶囊，持续2个月，并使用疼痛检测问卷进行评估。
结果
疼痛总体评分从基线时的17.3±5.9降至最终评估时的10.3±6.1（p<0.001）。77.4%的患者停止使用或减少了伴随的镇痛和抗炎治疗剂量。
结论
单磷酸尿苷 + 叶酸 + 维生素B12降低了总疼痛评分、疼痛强度、疼痛特征及相关症状。这些结果应在设计良好、样本量充足的随机对照试验中进行验证。
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